The facile production of N-methyl amino acids via oxazolidinones

Luigi Aurelio; Robert T.C. Brownlee; Andrew B. Hughes; Brad E. Sleebs

The facile production of N-methyl amino acids via oxazolidinones

Luigi Aurelio, Robert T.C. Brownlee, Andrew B. Hughes, Brad E. Sleebs

Research output: Contribution to journal › Article › Research › peer-review

Abstract

A range of oxazolidinones derived from N-carbamoyl α-amino acids were prepared by an efficient method as key intermediates in the synthesis of N-methyl amino acids and peptides. The method was readily applied to most α-amino acids except those with basic side chains. The oxazolidinones were converted by reductive cleavage into N-methyl α-amino acids.

Original language	English
Pages (from-to)	425-433
Number of pages	9
Journal	Australian Journal of Chemistry
Volume	53
Issue number	5
Publication status	Published - 1 Dec 2000
Externally published	Yes

Keywords

N-methyl amino acids
Oxazolidinones
Reductive cleavage
Synthesis

Cite this

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abstract = "A range of oxazolidinones derived from N-carbamoyl α-amino acids were prepared by an efficient method as key intermediates in the synthesis of N-methyl amino acids and peptides. The method was readily applied to most α-amino acids except those with basic side chains. The oxazolidinones were converted by reductive cleavage into N-methyl α-amino acids.",

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AU - Brownlee, Robert T.C.

AU - Hughes, Andrew B.

AU - Sleebs, Brad E.

PY - 2000/12/1

Y1 - 2000/12/1

N2 - A range of oxazolidinones derived from N-carbamoyl α-amino acids were prepared by an efficient method as key intermediates in the synthesis of N-methyl amino acids and peptides. The method was readily applied to most α-amino acids except those with basic side chains. The oxazolidinones were converted by reductive cleavage into N-methyl α-amino acids.

AB - A range of oxazolidinones derived from N-carbamoyl α-amino acids were prepared by an efficient method as key intermediates in the synthesis of N-methyl amino acids and peptides. The method was readily applied to most α-amino acids except those with basic side chains. The oxazolidinones were converted by reductive cleavage into N-methyl α-amino acids.

KW - N-methyl amino acids

KW - Oxazolidinones

KW - Reductive cleavage

KW - Synthesis

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EP - 433

JO - Australian Journal of Chemistry

JF - Australian Journal of Chemistry

IS - 5

ER -

The facile production of N-methyl amino acids via oxazolidinones

Abstract

Keywords

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