The expanding role of murine class Ib MHC in the development and activation of Natural Killer cells

Katharine J. Goodall, Angela Nguyen, Lucy C. Sullivan, Daniel M. Andrews

Research output: Contribution to journalReview ArticleOtherpeer-review

6 Citations (Scopus)

Abstract

Major Histocompatibility Complex-I (MHC-I) molecules can be divided into class Ia and class Ib, with three distinct class Ib families found in the mouse. These families are designated as Q, T and M and are largely unexplored in terms of their immunological function. Among the class Ib MHC, H2-T23 (Qa-1b) has been a significant target for Natural Killer (NK) cell research, owing to its homology with the human class Ib human leukocyte antigen (HLA)-E. However, recent data has indicated that members of the Q and M family of class Ib MHC also play a critical role in the development and regulation NK cells. Here we discuss the recent advances in the control of NK cells by murine class Ib MHC as a means to stimulate further exploration of these molecules.

Original languageEnglish
Pages (from-to)31-38
Number of pages8
JournalMolecular Immunology
Volume115
Issue numberSI
DOIs
Publication statusPublished - Nov 2019

Keywords

  • Major histocompatibility complex
  • Natural killer cell

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