The expanding role of murine class Ib MHC in the development and activation of Natural Killer cells

Katharine J. Goodall, Angela Nguyen, Lucy C. Sullivan, Daniel M. Andrews

Research output: Contribution to journalReview ArticleOtherpeer-review

2 Citations (Scopus)

Abstract

Major Histocompatibility Complex-I (MHC-I) molecules can be divided into class Ia and class Ib, with three distinct class Ib families found in the mouse. These families are designated as Q, T and M and are largely unexplored in terms of their immunological function. Among the class Ib MHC, H2-T23 (Qa-1b) has been a significant target for Natural Killer (NK) cell research, owing to its homology with the human class Ib human leukocyte antigen (HLA)-E. However, recent data has indicated that members of the Q and M family of class Ib MHC also play a critical role in the development and regulation NK cells. Here we discuss the recent advances in the control of NK cells by murine class Ib MHC as a means to stimulate further exploration of these molecules.

Original languageEnglish
Number of pages8
JournalMolecular Immunology
DOIs
Publication statusAccepted/In press - 1 Jan 2018

Keywords

  • Major histocompatibility complex
  • Natural killer cell

Cite this

@article{a851c9e15b234352b1232e77eb125df2,
title = "The expanding role of murine class Ib MHC in the development and activation of Natural Killer cells",
abstract = "Major Histocompatibility Complex-I (MHC-I) molecules can be divided into class Ia and class Ib, with three distinct class Ib families found in the mouse. These families are designated as Q, T and M and are largely unexplored in terms of their immunological function. Among the class Ib MHC, H2-T23 (Qa-1b) has been a significant target for Natural Killer (NK) cell research, owing to its homology with the human class Ib human leukocyte antigen (HLA)-E. However, recent data has indicated that members of the Q and M family of class Ib MHC also play a critical role in the development and regulation NK cells. Here we discuss the recent advances in the control of NK cells by murine class Ib MHC as a means to stimulate further exploration of these molecules.",
keywords = "Major histocompatibility complex, Natural killer cell",
author = "Goodall, {Katharine J.} and Angela Nguyen and Sullivan, {Lucy C.} and Andrews, {Daniel M.}",
year = "2018",
month = "1",
day = "1",
doi = "10.1016/j.molimm.2018.05.001",
language = "English",
journal = "Molecular Immunology",
issn = "0161-5890",
publisher = "Elsevier",

}

The expanding role of murine class Ib MHC in the development and activation of Natural Killer cells. / Goodall, Katharine J.; Nguyen, Angela; Sullivan, Lucy C.; Andrews, Daniel M.

In: Molecular Immunology, 01.01.2018.

Research output: Contribution to journalReview ArticleOtherpeer-review

TY - JOUR

T1 - The expanding role of murine class Ib MHC in the development and activation of Natural Killer cells

AU - Goodall, Katharine J.

AU - Nguyen, Angela

AU - Sullivan, Lucy C.

AU - Andrews, Daniel M.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Major Histocompatibility Complex-I (MHC-I) molecules can be divided into class Ia and class Ib, with three distinct class Ib families found in the mouse. These families are designated as Q, T and M and are largely unexplored in terms of their immunological function. Among the class Ib MHC, H2-T23 (Qa-1b) has been a significant target for Natural Killer (NK) cell research, owing to its homology with the human class Ib human leukocyte antigen (HLA)-E. However, recent data has indicated that members of the Q and M family of class Ib MHC also play a critical role in the development and regulation NK cells. Here we discuss the recent advances in the control of NK cells by murine class Ib MHC as a means to stimulate further exploration of these molecules.

AB - Major Histocompatibility Complex-I (MHC-I) molecules can be divided into class Ia and class Ib, with three distinct class Ib families found in the mouse. These families are designated as Q, T and M and are largely unexplored in terms of their immunological function. Among the class Ib MHC, H2-T23 (Qa-1b) has been a significant target for Natural Killer (NK) cell research, owing to its homology with the human class Ib human leukocyte antigen (HLA)-E. However, recent data has indicated that members of the Q and M family of class Ib MHC also play a critical role in the development and regulation NK cells. Here we discuss the recent advances in the control of NK cells by murine class Ib MHC as a means to stimulate further exploration of these molecules.

KW - Major histocompatibility complex

KW - Natural killer cell

UR - http://www.scopus.com/inward/record.url?scp=85047094458&partnerID=8YFLogxK

U2 - 10.1016/j.molimm.2018.05.001

DO - 10.1016/j.molimm.2018.05.001

M3 - Review Article

JO - Molecular Immunology

JF - Molecular Immunology

SN - 0161-5890

ER -