The evolving technology for continuous renal replacement therapy from current standards to high-volume hemofiltration

Claudio Ronco, Rinaldo Bellomo

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11 Citations (Scopus)


In 1977 a new treatment named continuous arteriovenous hemofiltration was described. The technique was subsequently modified and newer options were made available. The use of a blood pump with a venovenous blood access became popular, and the arteriovenous treatments were partially abandoned. At the same time, the hemofilters were equipped with a second port in the ultrafiltrate compartment, thus permitting the countercurrent circulation of dialysate. All of these modifications are today available as routine treatments; and special machines have also been designed to facilitate the clinical application of these techniques. Recently, some authors have claimed a better survival in patients treated with high-volume hemofiltration techniqes. It has also been hypothesized that such results were at least partially related to a better removal of noxious substances in the middle molecular weight range. The development of new techniques and new machines permits physicians to perform any form of renal replacement therapy with high efficiency and high clinical tolerance, reducing the incidence of complications.

Original languageEnglish
Pages (from-to)426-433
Number of pages8
JournalCurrent Opinion in Critical Care
Issue number6
Publication statusPublished - 1 Jan 1997
Externally publishedYes

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