TY - JOUR
T1 - The evolving ribosome: from non-coded peptide bond formation to sophisticated translation machinery
AU - Davidovich, Chen
AU - Belousoff, Matthew
AU - Bashan, Anat
AU - Yonath, Ada
PY - 2009
Y1 - 2009
N2 - Structural analysis supported by biochemical, mutagenesis and computational evidence, revealed that the contemporary ribosome s active site is a universal symmetrical pocket made of ribosomal RNA. This pocket seems to be the remnant of the proto-ribosome, a dimeric RNA assembly evolved by gene duplication, capable of autonomously catalyzing peptide bond formation and non-coded amino acid polymerization.
AB - Structural analysis supported by biochemical, mutagenesis and computational evidence, revealed that the contemporary ribosome s active site is a universal symmetrical pocket made of ribosomal RNA. This pocket seems to be the remnant of the proto-ribosome, a dimeric RNA assembly evolved by gene duplication, capable of autonomously catalyzing peptide bond formation and non-coded amino acid polymerization.
UR - http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19619641
U2 - 10.1016/j.resmic.2009.07.004
DO - 10.1016/j.resmic.2009.07.004
M3 - Article
SN - 0923-2508
VL - 160
SP - 487
EP - 492
JO - Research in Microbiology
JF - Research in Microbiology
IS - 7
ER -