The evolving ribosome: from non-coded peptide bond formation to sophisticated translation machinery

Chen Davidovich, Matthew Belousoff, Anat Bashan, Ada Yonath

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)

Abstract

Structural analysis supported by biochemical, mutagenesis and computational evidence, revealed that the contemporary ribosome s active site is a universal symmetrical pocket made of ribosomal RNA. This pocket seems to be the remnant of the proto-ribosome, a dimeric RNA assembly evolved by gene duplication, capable of autonomously catalyzing peptide bond formation and non-coded amino acid polymerization.
Original languageEnglish
Pages (from-to)487 - 492
Number of pages6
JournalResearch in Microbiology
Volume160
Issue number7
DOIs
Publication statusPublished - 2009
Externally publishedYes

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