The evolution of DNA vaccines

V. Apostolopoulos, M. Plebanski

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Abstract

Vaccination has eradicated smallpox and greatly decreased mortality and morbidity associated with a variety of viral and bacterial infectious diseases. However, conventional methodologies have failed to provide vaccines against many widespread deadly human diseases, among them HIV, malaria and cancer. Recombinant DNA vaccines have shown great promise in animal models in inducing protective immunity. In this review we will discuss their potential Safe Use in humans following recent advances in their use in animals, including non-human primates.

Original languageEnglish
Pages (from-to)441-447
Number of pages7
JournalCurrent Opinion in Molecular Therapeutics
Volume2
Issue number4
Publication statusPublished - 2000
Externally publishedYes

Keywords

  • Cancer
  • Cytokines
  • DNA vaccines
  • Immunotherapy
  • Infectious disease
  • Optimized vaccines
  • Primates
  • Prime/boost

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