Abstract
BACKGROUND: Uncertainty exists regarding the clinical relevance of exercise training across the range of interstitial lung diseases (ILDs).
OBJECTIVE: To establish the impact of exercise training in patients with ILDs of differing aetiology and severity.
METHODS: 142 participants with ILD (61 idiopathic pulmonary fibrosis (IPF), 22 asbestosis, 23 connective tissue disease-related ILD (CTD-ILD) and 36 with other aetiologies) were randomised to either 8 weeks of supervised exercise training or usual care. Six-minute walk distance (6MWD), Chronic Respiratory Disease Questionnaire (CRDQ), St George Respiratory Questionnaire IPF-specific version (SGRQ-I) and modified Medical Research Council dyspnoea score were measured at baseline, 9 weeks and 6 months.
MEASUREMENTS AND MAIN RESULTS: Exercise training significantly increased 6MWD (25 m, 95% CI 2 to 47 m) and health-related quality of life (CRDQ and SGRQ-I) in people with ILD. Larger improvements in 6MWD, CRDQ, SGRQ-I and dyspnoea occurred in asbestosis and IPF compared with CTD-ILD, but with few significant differences between subgroups. Benefits declined at 6 months except in CTD-ILD. Lower baseline 6MWD and worse baseline symptoms were associated with greater benefit in 6MWD and symptoms following training. Greater gains were seen in those whose exercise prescription was successfully progressed according to the protocol. At 6 months, sustained improvements in 6MWD and symptoms were associated with better baseline lung function and less pulmonary hypertension.
CONCLUSIONS: Exercise training is effective in patients across the range of ILDs, with clinically meaningful benefits in asbestosis and IPF. Successful exercise progression maximises improvements and sustained treatment effects favour those with milder disease.
TRIAL REGISTRATION NUMBER: Results, ACTRN12611000416998.
| Original language | English |
|---|---|
| Pages (from-to) | 610-619 |
| Number of pages | 10 |
| Journal | Thorax |
| Volume | 72 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 1 Jul 2017 |
Keywords
- Asbestos Induced Lung Disease
- Connective tissue disease associated lung disease
- Exercise
- Idiopathic pulmonary fibrosis
- Interstitial Fibrosis
- Pulmonary Rehabilitation
Cite this
}
The evidence of benefits of exercise training in interstitial lung disease : a randomised controlled trial. / Dowman, Leona M.; McDonald, Christine F.; Hill, Catherine J.; Lee, Annemarie L.; Barker, Kathryn; Boote, Claire; Glaspole, Ian; Goh, Nicole S.L.; Southcott, Anne M.; Burge, Angela T.; Gillies, Rebecca; Martin, Alicia; Holland, Anne E.
In: Thorax, Vol. 72, No. 7, 01.07.2017, p. 610-619.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - The evidence of benefits of exercise training in interstitial lung disease
T2 - a randomised controlled trial
AU - Dowman, Leona M.
AU - McDonald, Christine F.
AU - Hill, Catherine J.
AU - Lee, Annemarie L.
AU - Barker, Kathryn
AU - Boote, Claire
AU - Glaspole, Ian
AU - Goh, Nicole S.L.
AU - Southcott, Anne M.
AU - Burge, Angela T.
AU - Gillies, Rebecca
AU - Martin, Alicia
AU - Holland, Anne E.
PY - 2017/7/1
Y1 - 2017/7/1
N2 - BACKGROUND: Uncertainty exists regarding the clinical relevance of exercise training across the range of interstitial lung diseases (ILDs).OBJECTIVE: To establish the impact of exercise training in patients with ILDs of differing aetiology and severity.METHODS: 142 participants with ILD (61 idiopathic pulmonary fibrosis (IPF), 22 asbestosis, 23 connective tissue disease-related ILD (CTD-ILD) and 36 with other aetiologies) were randomised to either 8 weeks of supervised exercise training or usual care. Six-minute walk distance (6MWD), Chronic Respiratory Disease Questionnaire (CRDQ), St George Respiratory Questionnaire IPF-specific version (SGRQ-I) and modified Medical Research Council dyspnoea score were measured at baseline, 9 weeks and 6 months.MEASUREMENTS AND MAIN RESULTS: Exercise training significantly increased 6MWD (25 m, 95% CI 2 to 47 m) and health-related quality of life (CRDQ and SGRQ-I) in people with ILD. Larger improvements in 6MWD, CRDQ, SGRQ-I and dyspnoea occurred in asbestosis and IPF compared with CTD-ILD, but with few significant differences between subgroups. Benefits declined at 6 months except in CTD-ILD. Lower baseline 6MWD and worse baseline symptoms were associated with greater benefit in 6MWD and symptoms following training. Greater gains were seen in those whose exercise prescription was successfully progressed according to the protocol. At 6 months, sustained improvements in 6MWD and symptoms were associated with better baseline lung function and less pulmonary hypertension.CONCLUSIONS: Exercise training is effective in patients across the range of ILDs, with clinically meaningful benefits in asbestosis and IPF. Successful exercise progression maximises improvements and sustained treatment effects favour those with milder disease.TRIAL REGISTRATION NUMBER: Results, ACTRN12611000416998.
AB - BACKGROUND: Uncertainty exists regarding the clinical relevance of exercise training across the range of interstitial lung diseases (ILDs).OBJECTIVE: To establish the impact of exercise training in patients with ILDs of differing aetiology and severity.METHODS: 142 participants with ILD (61 idiopathic pulmonary fibrosis (IPF), 22 asbestosis, 23 connective tissue disease-related ILD (CTD-ILD) and 36 with other aetiologies) were randomised to either 8 weeks of supervised exercise training or usual care. Six-minute walk distance (6MWD), Chronic Respiratory Disease Questionnaire (CRDQ), St George Respiratory Questionnaire IPF-specific version (SGRQ-I) and modified Medical Research Council dyspnoea score were measured at baseline, 9 weeks and 6 months.MEASUREMENTS AND MAIN RESULTS: Exercise training significantly increased 6MWD (25 m, 95% CI 2 to 47 m) and health-related quality of life (CRDQ and SGRQ-I) in people with ILD. Larger improvements in 6MWD, CRDQ, SGRQ-I and dyspnoea occurred in asbestosis and IPF compared with CTD-ILD, but with few significant differences between subgroups. Benefits declined at 6 months except in CTD-ILD. Lower baseline 6MWD and worse baseline symptoms were associated with greater benefit in 6MWD and symptoms following training. Greater gains were seen in those whose exercise prescription was successfully progressed according to the protocol. At 6 months, sustained improvements in 6MWD and symptoms were associated with better baseline lung function and less pulmonary hypertension.CONCLUSIONS: Exercise training is effective in patients across the range of ILDs, with clinically meaningful benefits in asbestosis and IPF. Successful exercise progression maximises improvements and sustained treatment effects favour those with milder disease.TRIAL REGISTRATION NUMBER: Results, ACTRN12611000416998.
KW - Asbestos Induced Lung Disease
KW - Connective tissue disease associated lung disease
KW - Exercise
KW - Idiopathic pulmonary fibrosis
KW - Interstitial Fibrosis
KW - Pulmonary Rehabilitation
UR - http://www.scopus.com/inward/record.url?scp=85027989052&partnerID=8YFLogxK
U2 - 10.1136/thoraxjnl-2016-208638
DO - 10.1136/thoraxjnl-2016-208638
M3 - Article
VL - 72
SP - 610
EP - 619
JO - Thorax
JF - Thorax
SN - 0040-6376
IS - 7
ER -