The Ets transcription factor ELF5 functions as a tumor suppressor in the kidney

Erika Lapinskas, Suzanne Svobodova, Ian Davis, Jonathan Cebon, Paul Hertzog, Melanie Pritchard

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Abstract

Renal cell carcinoma is an important clinical disease with poorly understood etiology. ELF5 is an epithelial-specific member of the Ets family of transcription factors, characterized by the 80 amino acid Ets domain that binds the purine-rich GGAA/T Ets motif found in the promoter regions of a variety of genes. Since ELF5 is highly expressed in kidney and has been postulated to function as a tumor suppressor, at least in the context of the breast, we investigated its role in kidney cancer. In renal cell carcinoma ELF5 expression was consistently decreased in tumor samples versus normal. ELF5 mRNA was decreased in 94 of lesions tested and ELF5 protein was undetectable in 40/40 kidney-derived carcinomas. Re-expression of the ELF5 gene in 786-O renal carcinoma cells suppressed their tumorigenic capacity in vitro and in vivo. This work is the first to suggest that ELF5 has tumor suppressor activity in the kidney.
Original languageEnglish
Pages (from-to)316 - 322
Number of pages7
JournalTwin Research and Human Genetics
Volume14
Issue number4
DOIs
Publication statusPublished - 2011

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