Abstract
The Epilepsy Bioinformatics Study for Anti-epileptogenic Therapy (EpiBioS4Rx) is a longitudinal prospective observational study funded by the National Institute of Health (NIH) to discover and validate observational biomarkers of epileptogenesis after traumatic brain injury (TBI). A multidisciplinary approach has been incorporated to investigate acute electrical, neuroanatomical, and blood biomarkers after TBI that may predict the development of post-traumatic epilepsy (PTE). We plan to enroll 300 moderate-severe TBI patients with a frontal and/or temporal lobe hemorrhagic contusion. Acute evaluation with blood, imaging and electroencephalographic monitoring will be performed and then patients will be tracked for 2 years to determine the incidence of PTE. Validation of selected biomarkers that are discovered in planned animal models will be a principal feature of this work. Specific hypotheses regarding the discovery of biomarkers have been set forth in this study. An international cohort of 13 centers spanning 2 continents will be developed to facilitate this study, and for future interventional studies.
| Original language | English |
|---|---|
| Pages (from-to) | 110-114 |
| Number of pages | 5 |
| Journal | Neurobiology of Disease |
| Volume | 123 |
| DOIs | |
| Publication status | Published - 1 Mar 2019 |
| Externally published | Yes |
Cite this
}
The epilepsy bioinformatics study for anti-epileptogenic therapy (EpiBioS4Rx) clinical biomarker : Study design and protocol. / Vespa, Paul M.; Shrestha, Vikesh; Abend, Nicholas; Agoston, Denes; Au, Alicia; Bell, Michael J.; Bleck, Thomas P.; Blanco, Manuel Buitrago; Ellingson, Ben; Gilmore, Emily J.; Hirsch, Lawrence; Hunn, Martin; Kamnaksh, Alaa; McArthur, David; Morokoff, Andrew; O'Brien, Terrence; O'Phelan, Kristine; Robertson, Courtney L.; Rosenthal, Eric; Staba, Richard; Willyerd, Frederick A.; Yam, Elisa; Martinez, Susana; Real, Courtney; Engel, Jerome; For the EpiBioS4Rx Study Group; Agoston, Denes; Au, Alicia; Bell, Michael J.; Bleck Thomas, P.; Branch, Craig; Buitrago Blanco, Manuel; Bullock, Ross; Burrows, Brian T.; Claassen, Jan; Clarke, Robert; Cloyd, James; Coles, Lisa; Crawford, Karen; Diaz-Arrastia, Ramon; Duncan, Dominique; Ellingson, Benjamin; Engel, Jerome; Foreman, Brandon; Galanopoulou, Aristea; Gilmore, Emily; Grohn, Olli; Harris, Neil; Hartings, Jed; Lawrence, Hirsch; Jette, Nathalie; Johnston, Leigh; Jones, Nigel; Kanner, Andres; McArthur, David; Monti, Martin; Morokoff, Andrew; Moshe, Solomon; Mowrey, Wenzhu; O'Phelan, Kristine; Pitkanen, Asla; Raman, Rema; Robertson, Courtney; Rosenthal, Eric; Shultz, Sandy; Snutch, Terrance; Staba, Richard; Toga, Arthur; Van Horn, Jack; Vespa, Paul; Willyerd, Frederick; Zimmermann, Lara.
In: Neurobiology of Disease, Vol. 123, 01.03.2019, p. 110-114.Research output: Contribution to journal › Review Article › Other › peer-review
TY - JOUR
T1 - The epilepsy bioinformatics study for anti-epileptogenic therapy (EpiBioS4Rx) clinical biomarker
T2 - Study design and protocol
AU - Vespa, Paul M.
AU - Shrestha, Vikesh
AU - Abend, Nicholas
AU - Agoston, Denes
AU - Au, Alicia
AU - Bell, Michael J.
AU - Bleck, Thomas P.
AU - Blanco, Manuel Buitrago
AU - Ellingson, Ben
AU - Gilmore, Emily J.
AU - Hirsch, Lawrence
AU - Hunn, Martin
AU - Kamnaksh, Alaa
AU - McArthur, David
AU - Morokoff, Andrew
AU - O'Brien, Terrence
AU - O'Phelan, Kristine
AU - Robertson, Courtney L.
AU - Rosenthal, Eric
AU - Staba, Richard
AU - Willyerd, Frederick A.
AU - Yam, Elisa
AU - Martinez, Susana
AU - Real, Courtney
AU - Engel, Jerome
AU - For the EpiBioS4Rx Study Group
AU - Agoston, Denes
AU - Au, Alicia
AU - Bell, Michael J.
AU - Bleck Thomas, P.
AU - Branch, Craig
AU - Buitrago Blanco, Manuel
AU - Bullock, Ross
AU - Burrows, Brian T.
AU - Claassen, Jan
AU - Clarke, Robert
AU - Cloyd, James
AU - Coles, Lisa
AU - Crawford, Karen
AU - Diaz-Arrastia, Ramon
AU - Duncan, Dominique
AU - Ellingson, Benjamin
AU - Engel, Jerome
AU - Foreman, Brandon
AU - Galanopoulou, Aristea
AU - Gilmore, Emily
AU - Grohn, Olli
AU - Harris, Neil
AU - Hartings, Jed
AU - Lawrence, Hirsch
AU - Jette, Nathalie
AU - Johnston, Leigh
AU - Jones, Nigel
AU - Kanner, Andres
AU - McArthur, David
AU - Monti, Martin
AU - Morokoff, Andrew
AU - Moshe, Solomon
AU - Mowrey, Wenzhu
AU - O'Phelan, Kristine
AU - Pitkanen, Asla
AU - Raman, Rema
AU - Robertson, Courtney
AU - Rosenthal, Eric
AU - Shultz, Sandy
AU - Snutch, Terrance
AU - Staba, Richard
AU - Toga, Arthur
AU - Van Horn, Jack
AU - Vespa, Paul
AU - Willyerd, Frederick
AU - Zimmermann, Lara
PY - 2019/3/1
Y1 - 2019/3/1
N2 - The Epilepsy Bioinformatics Study for Anti-epileptogenic Therapy (EpiBioS4Rx) is a longitudinal prospective observational study funded by the National Institute of Health (NIH) to discover and validate observational biomarkers of epileptogenesis after traumatic brain injury (TBI). A multidisciplinary approach has been incorporated to investigate acute electrical, neuroanatomical, and blood biomarkers after TBI that may predict the development of post-traumatic epilepsy (PTE). We plan to enroll 300 moderate-severe TBI patients with a frontal and/or temporal lobe hemorrhagic contusion. Acute evaluation with blood, imaging and electroencephalographic monitoring will be performed and then patients will be tracked for 2 years to determine the incidence of PTE. Validation of selected biomarkers that are discovered in planned animal models will be a principal feature of this work. Specific hypotheses regarding the discovery of biomarkers have been set forth in this study. An international cohort of 13 centers spanning 2 continents will be developed to facilitate this study, and for future interventional studies.
AB - The Epilepsy Bioinformatics Study for Anti-epileptogenic Therapy (EpiBioS4Rx) is a longitudinal prospective observational study funded by the National Institute of Health (NIH) to discover and validate observational biomarkers of epileptogenesis after traumatic brain injury (TBI). A multidisciplinary approach has been incorporated to investigate acute electrical, neuroanatomical, and blood biomarkers after TBI that may predict the development of post-traumatic epilepsy (PTE). We plan to enroll 300 moderate-severe TBI patients with a frontal and/or temporal lobe hemorrhagic contusion. Acute evaluation with blood, imaging and electroencephalographic monitoring will be performed and then patients will be tracked for 2 years to determine the incidence of PTE. Validation of selected biomarkers that are discovered in planned animal models will be a principal feature of this work. Specific hypotheses regarding the discovery of biomarkers have been set forth in this study. An international cohort of 13 centers spanning 2 continents will be developed to facilitate this study, and for future interventional studies.
UR - http://www.scopus.com/inward/record.url?scp=85050387436&partnerID=8YFLogxK
U2 - 10.1016/j.nbd.2018.07.025
DO - 10.1016/j.nbd.2018.07.025
M3 - Review Article
VL - 123
SP - 110
EP - 114
JO - Neurobiology of Disease
JF - Neurobiology of Disease
SN - 0969-9961
ER -