The epilepsy bioinformatics study for anti-epileptogenic therapy (EpiBioS4Rx) clinical biomarker: Study design and protocol

Paul M. Vespa, Vikesh Shrestha, Nicholas Abend, Denes Agoston, Alicia Au, Michael J. Bell, Thomas P. Bleck, Manuel Buitrago Blanco, Ben Ellingson, Emily J. Gilmore, Lawrence Hirsch, Martin Hunn, Alaa Kamnaksh, David McArthur, Andrew Morokoff, Terrence O'Brien, Kristine O'Phelan, Courtney L. Robertson, Eric Rosenthal, Richard StabaFrederick A. Willyerd, Elisa Yam, Susana Martinez, Courtney Real, Jerome Engel, for the EpiBioS4Rx Study Group, Denes Agoston, Alicia Au, Michael J. Bell, P. Bleck Thomas, Craig Branch, Manuel Buitrago Blanco, Ross Bullock, Brian T. Burrows, Jan Claassen, Robert Clarke, James Cloyd, Lisa Coles, Karen Crawford, Ramon Diaz-Arrastia, Dominique Duncan, Benjamin Ellingson, Jerome Engel, Brandon Foreman, Aristea Galanopoulou, Emily Gilmore, Olli Grohn, Neil Harris, Jed Hartings, Hirsch Lawrence, Nathalie Jette, Leigh Johnston, Nigel Jones, Andres Kanner, David McArthur, Martin Monti, Andrew Morokoff, Solomon Moshe, Wenzhu Mowrey, Kristine O'Phelan, Asla Pitkanen, Rema Raman, Courtney Robertson, Eric Rosenthal, Sandy Shultz, Terrance Snutch, Richard Staba, Arthur Toga, Jack Van Horn, Paul Vespa, Frederick Willyerd, Lara Zimmermann

Research output: Contribution to journalReview ArticleOtherpeer-review

8 Citations (Scopus)

Abstract

The Epilepsy Bioinformatics Study for Anti-epileptogenic Therapy (EpiBioS4Rx) is a longitudinal prospective observational study funded by the National Institute of Health (NIH) to discover and validate observational biomarkers of epileptogenesis after traumatic brain injury (TBI). A multidisciplinary approach has been incorporated to investigate acute electrical, neuroanatomical, and blood biomarkers after TBI that may predict the development of post-traumatic epilepsy (PTE). We plan to enroll 300 moderate-severe TBI patients with a frontal and/or temporal lobe hemorrhagic contusion. Acute evaluation with blood, imaging and electroencephalographic monitoring will be performed and then patients will be tracked for 2 years to determine the incidence of PTE. Validation of selected biomarkers that are discovered in planned animal models will be a principal feature of this work. Specific hypotheses regarding the discovery of biomarkers have been set forth in this study. An international cohort of 13 centers spanning 2 continents will be developed to facilitate this study, and for future interventional studies.

Original languageEnglish
Pages (from-to)110-114
Number of pages5
JournalNeurobiology of Disease
Volume123
DOIs
Publication statusPublished - 1 Mar 2019
Externally publishedYes

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