The epilepsy bioinformatics study for anti-epileptogenic therapy (EpiBioS4Rx) clinical biomarker: Study design and protocol

Paul M. Vespa; Vikesh Shrestha; Nicholas Abend; Denes Agoston; Alicia Au; Michael J. Bell; Thomas P. Bleck; Manuel Buitrago Blanco; Ben Ellingson; Emily J. Gilmore; Lawrence Hirsch; Martin Hunn; Alaa Kamnaksh; David McArthur; Andrew Morokoff; Terrence O'Brien; Kristine O'Phelan; Courtney L. Robertson; Eric Rosenthal; Richard Staba; Frederick A. Willyerd; Elisa Yam; Susana Martinez; Courtney Real; Jerome Engel; for the EpiBioS4Rx Study Group; Denes Agoston; Alicia Au; Michael J. Bell; P. Bleck Thomas; Craig Branch; Manuel Buitrago Blanco; Ross Bullock; Brian T. Burrows; Jan Claassen; Robert Clarke; James Cloyd; Lisa Coles; Karen Crawford; Ramon Diaz-Arrastia; Dominique Duncan; Benjamin Ellingson; Jerome Engel; Brandon Foreman; Aristea Galanopoulou; Emily Gilmore; Olli Grohn; Neil Harris; Jed Hartings; Hirsch Lawrence; Nathalie Jette; Leigh Johnston; Nigel Jones; Andres Kanner; David McArthur; Martin Monti; Andrew Morokoff; Solomon Moshe; Wenzhu Mowrey; Kristine O'Phelan; Asla Pitkanen; Rema Raman; Courtney Robertson; Eric Rosenthal; Sandy Shultz; Terrance Snutch; Richard Staba; Arthur Toga; Jack Van Horn; Paul Vespa; Frederick Willyerd; Lara Zimmermann

doi:10.1016/j.nbd.2018.07.025

The epilepsy bioinformatics study for anti-epileptogenic therapy (EpiBioS4Rx) clinical biomarker: Study design and protocol

Paul M. Vespa, Vikesh Shrestha, Nicholas Abend, Denes Agoston, Alicia Au, Michael J. Bell, Thomas P. Bleck, Manuel Buitrago Blanco, Ben Ellingson, Emily J. Gilmore, Lawrence Hirsch, Martin Hunn, Alaa Kamnaksh, David McArthur, Andrew Morokoff, Terrence O'Brien, Kristine O'Phelan, Courtney L. Robertson, Eric Rosenthal, Richard StabaFrederick A. Willyerd, Elisa Yam, Susana Martinez, Courtney Real, Jerome Engel, for the EpiBioS4Rx Study Group, Denes Agoston, Alicia Au, Michael J. Bell, P. Bleck Thomas, Craig Branch, Manuel Buitrago Blanco, Ross Bullock, Brian T. Burrows, Jan Claassen, Robert Clarke, James Cloyd, Lisa Coles, Karen Crawford, Ramon Diaz-Arrastia, Dominique Duncan, Benjamin Ellingson, Jerome Engel, Brandon Foreman, Aristea Galanopoulou, Emily Gilmore, Olli Grohn, Neil Harris, Jed Hartings, Hirsch Lawrence, Nathalie Jette, Leigh Johnston, Nigel Jones, Andres Kanner, David McArthur, Martin Monti, Andrew Morokoff, Solomon Moshe, Wenzhu Mowrey, Kristine O'Phelan, Asla Pitkanen, Rema Raman, Courtney Robertson, Eric Rosenthal, Sandy Shultz, Terrance Snutch, Richard Staba, Arthur Toga, Jack Van Horn, Paul Vespa, Frederick Willyerd, Lara Zimmermann

Research output: Contribution to journal › Review Article › Other › peer-review

8 Citations (Scopus)

Abstract

The Epilepsy Bioinformatics Study for Anti-epileptogenic Therapy (EpiBioS4Rx) is a longitudinal prospective observational study funded by the National Institute of Health (NIH) to discover and validate observational biomarkers of epileptogenesis after traumatic brain injury (TBI). A multidisciplinary approach has been incorporated to investigate acute electrical, neuroanatomical, and blood biomarkers after TBI that may predict the development of post-traumatic epilepsy (PTE). We plan to enroll 300 moderate-severe TBI patients with a frontal and/or temporal lobe hemorrhagic contusion. Acute evaluation with blood, imaging and electroencephalographic monitoring will be performed and then patients will be tracked for 2 years to determine the incidence of PTE. Validation of selected biomarkers that are discovered in planned animal models will be a principal feature of this work. Specific hypotheses regarding the discovery of biomarkers have been set forth in this study. An international cohort of 13 centers spanning 2 continents will be developed to facilitate this study, and for future interventional studies.

Original language	English
Pages (from-to)	110-114
Number of pages	5
Journal	Neurobiology of Disease
Volume	123
DOIs	https://doi.org/10.1016/j.nbd.2018.07.025
Publication status	Published - 1 Mar 2019
Externally published	Yes

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10.1016/j.nbd.2018.07.025

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Cite this

Vespa, P. M., Shrestha, V., Abend, N., Agoston, D., Au, A., Bell, M. J., Bleck, T. P., Blanco, M. B., Ellingson, B., Gilmore, E. J., Hirsch, L., Hunn, M., Kamnaksh, A., McArthur, D., Morokoff, A., O'Brien, T., O'Phelan, K., Robertson, C. L., Rosenthal, E., ... Zimmermann, L. (2019). The epilepsy bioinformatics study for anti-epileptogenic therapy (EpiBioS4Rx) clinical biomarker: Study design and protocol. Neurobiology of Disease, 123, 110-114. https://doi.org/10.1016/j.nbd.2018.07.025

Vespa, Paul M. ; Shrestha, Vikesh ; Abend, Nicholas ; Agoston, Denes ; Au, Alicia ; Bell, Michael J. ; Bleck, Thomas P. ; Blanco, Manuel Buitrago ; Ellingson, Ben ; Gilmore, Emily J. ; Hirsch, Lawrence ; Hunn, Martin ; Kamnaksh, Alaa ; McArthur, David ; Morokoff, Andrew ; O'Brien, Terrence ; O'Phelan, Kristine ; Robertson, Courtney L. ; Rosenthal, Eric ; Staba, Richard ; Willyerd, Frederick A. ; Yam, Elisa ; Martinez, Susana ; Real, Courtney ; Engel, Jerome ; for the EpiBioS4Rx Study Group ; Agoston, Denes ; Au, Alicia ; Bell, Michael J. ; Bleck Thomas, P. ; Branch, Craig ; Buitrago Blanco, Manuel ; Bullock, Ross ; Burrows, Brian T. ; Claassen, Jan ; Clarke, Robert ; Cloyd, James ; Coles, Lisa ; Crawford, Karen ; Diaz-Arrastia, Ramon ; Duncan, Dominique ; Ellingson, Benjamin ; Engel, Jerome ; Foreman, Brandon ; Galanopoulou, Aristea ; Gilmore, Emily ; Grohn, Olli ; Harris, Neil ; Hartings, Jed ; Lawrence, Hirsch ; Jette, Nathalie ; Johnston, Leigh ; Jones, Nigel ; Kanner, Andres ; McArthur, David ; Monti, Martin ; Morokoff, Andrew ; Moshe, Solomon ; Mowrey, Wenzhu ; O'Phelan, Kristine ; Pitkanen, Asla ; Raman, Rema ; Robertson, Courtney ; Rosenthal, Eric ; Shultz, Sandy ; Snutch, Terrance ; Staba, Richard ; Toga, Arthur ; Van Horn, Jack ; Vespa, Paul ; Willyerd, Frederick ; Zimmermann, Lara. / The epilepsy bioinformatics study for anti-epileptogenic therapy (EpiBioS4Rx) clinical biomarker : Study design and protocol. In: Neurobiology of Disease. 2019 ; Vol. 123. pp. 110-114.

@article{5fc5c503cf114c48920594ba9d7924b4,

title = "The epilepsy bioinformatics study for anti-epileptogenic therapy (EpiBioS4Rx) clinical biomarker: Study design and protocol",

abstract = "The Epilepsy Bioinformatics Study for Anti-epileptogenic Therapy (EpiBioS4Rx) is a longitudinal prospective observational study funded by the National Institute of Health (NIH) to discover and validate observational biomarkers of epileptogenesis after traumatic brain injury (TBI). A multidisciplinary approach has been incorporated to investigate acute electrical, neuroanatomical, and blood biomarkers after TBI that may predict the development of post-traumatic epilepsy (PTE). We plan to enroll 300 moderate-severe TBI patients with a frontal and/or temporal lobe hemorrhagic contusion. Acute evaluation with blood, imaging and electroencephalographic monitoring will be performed and then patients will be tracked for 2 years to determine the incidence of PTE. Validation of selected biomarkers that are discovered in planned animal models will be a principal feature of this work. Specific hypotheses regarding the discovery of biomarkers have been set forth in this study. An international cohort of 13 centers spanning 2 continents will be developed to facilitate this study, and for future interventional studies.",

author = "Vespa, {Paul M.} and Vikesh Shrestha and Nicholas Abend and Denes Agoston and Alicia Au and Bell, {Michael J.} and Bleck, {Thomas P.} and Blanco, {Manuel Buitrago} and Ben Ellingson and Gilmore, {Emily J.} and Lawrence Hirsch and Martin Hunn and Alaa Kamnaksh and David McArthur and Andrew Morokoff and Terrence O'Brien and Kristine O'Phelan and Robertson, {Courtney L.} and Eric Rosenthal and Richard Staba and Willyerd, {Frederick A.} and Elisa Yam and Susana Martinez and Courtney Real and Jerome Engel and {for the EpiBioS4Rx Study Group} and Denes Agoston and Alicia Au and Bell, {Michael J.} and {Bleck Thomas}, P. and Craig Branch and {Buitrago Blanco}, Manuel and Ross Bullock and Burrows, {Brian T.} and Jan Claassen and Robert Clarke and James Cloyd and Lisa Coles and Karen Crawford and Ramon Diaz-Arrastia and Dominique Duncan and Benjamin Ellingson and Jerome Engel and Brandon Foreman and Aristea Galanopoulou and Emily Gilmore and Olli Grohn and Neil Harris and Jed Hartings and Hirsch Lawrence and Nathalie Jette and Leigh Johnston and Nigel Jones and Andres Kanner and David McArthur and Martin Monti and Andrew Morokoff and Solomon Moshe and Wenzhu Mowrey and Kristine O'Phelan and Asla Pitkanen and Rema Raman and Courtney Robertson and Eric Rosenthal and Sandy Shultz and Terrance Snutch and Richard Staba and Arthur Toga and {Van Horn}, Jack and Paul Vespa and Frederick Willyerd and Lara Zimmermann",

year = "2019",

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doi = "10.1016/j.nbd.2018.07.025",

language = "English",

volume = "123",

pages = "110--114",

journal = "Neurobiology of Disease",

issn = "0969-9961",

publisher = "Elsevier",

}

Vespa, PM, Shrestha, V, Abend, N, Agoston, D, Au, A, Bell, MJ, Bleck, TP, Blanco, MB, Ellingson, B, Gilmore, EJ, Hirsch, L, Hunn, M, Kamnaksh, A, McArthur, D, Morokoff, A, O'Brien, T, O'Phelan, K, Robertson, CL, Rosenthal, E, Staba, R, Willyerd, FA, Yam, E, Martinez, S, Real, C, Engel, J, for the EpiBioS4Rx Study Group, Agoston, D, Au, A, Bell, MJ, Bleck Thomas, P, Branch, C, Buitrago Blanco, M, Bullock, R, Burrows, BT, Claassen, J, Clarke, R, Cloyd, J, Coles, L, Crawford, K, Diaz-Arrastia, R, Duncan, D, Ellingson, B, Engel, J, Foreman, B, Galanopoulou, A, Gilmore, E, Grohn, O, Harris, N, Hartings, J, Lawrence, H, Jette, N, Johnston, L, Jones, N, Kanner, A, McArthur, D, Monti, M, Morokoff, A, Moshe, S, Mowrey, W, O'Phelan, K, Pitkanen, A, Raman, R, Robertson, C, Rosenthal, E, Shultz, S, Snutch, T, Staba, R, Toga, A, Van Horn, J, Vespa, P, Willyerd, F & Zimmermann, L 2019, 'The epilepsy bioinformatics study for anti-epileptogenic therapy (EpiBioS4Rx) clinical biomarker: Study design and protocol', Neurobiology of Disease, vol. 123, pp. 110-114. https://doi.org/10.1016/j.nbd.2018.07.025

The epilepsy bioinformatics study for anti-epileptogenic therapy (EpiBioS4Rx) clinical biomarker : Study design and protocol. / Vespa, Paul M.; Shrestha, Vikesh; Abend, Nicholas; Agoston, Denes; Au, Alicia; Bell, Michael J.; Bleck, Thomas P.; Blanco, Manuel Buitrago; Ellingson, Ben; Gilmore, Emily J.; Hirsch, Lawrence; Hunn, Martin; Kamnaksh, Alaa; McArthur, David; Morokoff, Andrew; O'Brien, Terrence; O'Phelan, Kristine; Robertson, Courtney L.; Rosenthal, Eric; Staba, Richard; Willyerd, Frederick A.; Yam, Elisa; Martinez, Susana; Real, Courtney; Engel, Jerome; for the EpiBioS4Rx Study Group; Agoston, Denes; Au, Alicia; Bell, Michael J.; Bleck Thomas, P.; Branch, Craig; Buitrago Blanco, Manuel; Bullock, Ross; Burrows, Brian T.; Claassen, Jan; Clarke, Robert; Cloyd, James; Coles, Lisa; Crawford, Karen; Diaz-Arrastia, Ramon; Duncan, Dominique; Ellingson, Benjamin; Engel, Jerome; Foreman, Brandon; Galanopoulou, Aristea; Gilmore, Emily; Grohn, Olli; Harris, Neil; Hartings, Jed; Lawrence, Hirsch; Jette, Nathalie; Johnston, Leigh; Jones, Nigel; Kanner, Andres; McArthur, David; Monti, Martin; Morokoff, Andrew; Moshe, Solomon; Mowrey, Wenzhu; O'Phelan, Kristine; Pitkanen, Asla; Raman, Rema; Robertson, Courtney; Rosenthal, Eric; Shultz, Sandy; Snutch, Terrance; Staba, Richard; Toga, Arthur; Van Horn, Jack; Vespa, Paul; Willyerd, Frederick; Zimmermann, Lara.

In: Neurobiology of Disease, Vol. 123, 01.03.2019, p. 110-114.

Research output: Contribution to journal › Review Article › Other › peer-review

TY - JOUR

T1 - The epilepsy bioinformatics study for anti-epileptogenic therapy (EpiBioS4Rx) clinical biomarker

T2 - Study design and protocol

AU - Vespa, Paul M.

AU - Shrestha, Vikesh

AU - Abend, Nicholas

AU - Agoston, Denes

AU - Au, Alicia

AU - Bell, Michael J.

AU - Bleck, Thomas P.

AU - Blanco, Manuel Buitrago

AU - Ellingson, Ben

AU - Gilmore, Emily J.

AU - Hirsch, Lawrence

AU - Hunn, Martin

AU - Kamnaksh, Alaa

AU - McArthur, David

AU - Morokoff, Andrew

AU - O'Brien, Terrence

AU - O'Phelan, Kristine

AU - Robertson, Courtney L.

AU - Rosenthal, Eric

AU - Staba, Richard

AU - Willyerd, Frederick A.

AU - Yam, Elisa

AU - Martinez, Susana

AU - Real, Courtney

AU - Engel, Jerome

AU - for the EpiBioS4Rx Study Group

AU - Agoston, Denes

AU - Au, Alicia

AU - Bell, Michael J.

AU - Bleck Thomas, P.

AU - Branch, Craig

AU - Buitrago Blanco, Manuel

AU - Bullock, Ross

AU - Burrows, Brian T.

AU - Claassen, Jan

AU - Clarke, Robert

AU - Cloyd, James

AU - Coles, Lisa

AU - Crawford, Karen

AU - Diaz-Arrastia, Ramon

AU - Duncan, Dominique

AU - Ellingson, Benjamin

AU - Engel, Jerome

AU - Foreman, Brandon

AU - Galanopoulou, Aristea

AU - Gilmore, Emily

AU - Grohn, Olli

AU - Harris, Neil

AU - Hartings, Jed

AU - Lawrence, Hirsch

AU - Jette, Nathalie

AU - Johnston, Leigh

AU - Jones, Nigel

AU - Kanner, Andres

AU - McArthur, David

AU - Monti, Martin

AU - Morokoff, Andrew

AU - Moshe, Solomon

AU - Mowrey, Wenzhu

AU - O'Phelan, Kristine

AU - Pitkanen, Asla

AU - Raman, Rema

AU - Robertson, Courtney

AU - Rosenthal, Eric

AU - Shultz, Sandy

AU - Snutch, Terrance

AU - Staba, Richard

AU - Toga, Arthur

AU - Van Horn, Jack

AU - Vespa, Paul

AU - Willyerd, Frederick

AU - Zimmermann, Lara

PY - 2019/3/1

Y1 - 2019/3/1

N2 - The Epilepsy Bioinformatics Study for Anti-epileptogenic Therapy (EpiBioS4Rx) is a longitudinal prospective observational study funded by the National Institute of Health (NIH) to discover and validate observational biomarkers of epileptogenesis after traumatic brain injury (TBI). A multidisciplinary approach has been incorporated to investigate acute electrical, neuroanatomical, and blood biomarkers after TBI that may predict the development of post-traumatic epilepsy (PTE). We plan to enroll 300 moderate-severe TBI patients with a frontal and/or temporal lobe hemorrhagic contusion. Acute evaluation with blood, imaging and electroencephalographic monitoring will be performed and then patients will be tracked for 2 years to determine the incidence of PTE. Validation of selected biomarkers that are discovered in planned animal models will be a principal feature of this work. Specific hypotheses regarding the discovery of biomarkers have been set forth in this study. An international cohort of 13 centers spanning 2 continents will be developed to facilitate this study, and for future interventional studies.

AB - The Epilepsy Bioinformatics Study for Anti-epileptogenic Therapy (EpiBioS4Rx) is a longitudinal prospective observational study funded by the National Institute of Health (NIH) to discover and validate observational biomarkers of epileptogenesis after traumatic brain injury (TBI). A multidisciplinary approach has been incorporated to investigate acute electrical, neuroanatomical, and blood biomarkers after TBI that may predict the development of post-traumatic epilepsy (PTE). We plan to enroll 300 moderate-severe TBI patients with a frontal and/or temporal lobe hemorrhagic contusion. Acute evaluation with blood, imaging and electroencephalographic monitoring will be performed and then patients will be tracked for 2 years to determine the incidence of PTE. Validation of selected biomarkers that are discovered in planned animal models will be a principal feature of this work. Specific hypotheses regarding the discovery of biomarkers have been set forth in this study. An international cohort of 13 centers spanning 2 continents will be developed to facilitate this study, and for future interventional studies.

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U2 - 10.1016/j.nbd.2018.07.025

DO - 10.1016/j.nbd.2018.07.025

M3 - Review Article

AN - SCOPUS:85050387436

VL - 123

SP - 110

EP - 114

JO - Neurobiology of Disease

JF - Neurobiology of Disease

SN - 0969-9961

ER -