The epidemiology, pathophysiological mechanisms, and management toward COVID-19 patients with Type 2 diabetes: a systematic review

Yun Yin; Kristen E. Rohli; Pengyue Shen; Haonan Lu; Yuenan Liu; Qingyu Dou; Lin Zhang; Xiangyi Kong; Shujuan Yang; Peng Jia

doi:10.1016/j.pcd.2021.08.014

The epidemiology, pathophysiological mechanisms, and management toward COVID-19 patients with Type 2 diabetes: a systematic review

Yun Yin, Kristen E. Rohli, Pengyue Shen, Haonan Lu, Yuenan Liu, Qingyu Dou, Lin Zhang, Xiangyi Kong, Shujuan Yang, Peng Jia

Research output: Contribution to journal › Review Article › Research › peer-review

18 Citations (Scopus)

Abstract

This review comprehensively summarizes epidemiologic evidence of COVID-19 in patients with Type 2 diabetes, explores pathophysiological mechanisms, and integrates recommendations and guidelines for patient management. We found that diabetes was a risk factor for diagnosed infection and poor prognosis of COVID-19. Patients with diabetes may be more susceptible to adverse outcomes associated with SARS-CoV-2 infection due to impaired immune function and possible upregulation of enzymes that mediate viral invasion. The chronic inflammation caused by diabetes, coupled with the acute inflammatory reaction caused by SARS-CoV-2, results in a propensity for inflammatory storm. Patients with diabetes should be aware of their increased risk for COVID-19.

Original language	English
Pages (from-to)	899-909
Number of pages	11
Journal	Primary Care Diabetes
Volume	15
Issue number	6
DOIs	https://doi.org/10.1016/j.pcd.2021.08.014
Publication status	Published - Dec 2021
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

COVID-19
Diabetes
Epidemiology
Management
Pathophysiological mechanism
SARS-CoV-2

Access to Document

10.1016/j.pcd.2021.08.014

Cite this

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title = "The epidemiology, pathophysiological mechanisms, and management toward COVID-19 patients with Type 2 diabetes: a systematic review",

abstract = "This review comprehensively summarizes epidemiologic evidence of COVID-19 in patients with Type 2 diabetes, explores pathophysiological mechanisms, and integrates recommendations and guidelines for patient management. We found that diabetes was a risk factor for diagnosed infection and poor prognosis of COVID-19. Patients with diabetes may be more susceptible to adverse outcomes associated with SARS-CoV-2 infection due to impaired immune function and possible upregulation of enzymes that mediate viral invasion. The chronic inflammation caused by diabetes, coupled with the acute inflammatory reaction caused by SARS-CoV-2, results in a propensity for inflammatory storm. Patients with diabetes should be aware of their increased risk for COVID-19.",

keywords = "COVID-19, Diabetes, Epidemiology, Management, Pathophysiological mechanism, SARS-CoV-2",

author = "Yun Yin and Rohli, \{Kristen E.\} and Pengyue Shen and Haonan Lu and Yuenan Liu and Qingyu Dou and Lin Zhang and Xiangyi Kong and Shujuan Yang and Peng Jia",

note = "Funding Information: We thank Prof. Donna Ryan (President of the World Obesity Federation and professor Emerita at Pennington Biomedical in Baton Rouge, Louisiana, US) for the critical comments and revisions to improve the quality of this study. We also thank the International Institute of Spatial Lifecourse Epidemiology (ISLE) for the research support. Publisher Copyright: {\textcopyright} 2021 Primary Care Diabetes Europe",

year = "2021",

month = dec,

doi = "10.1016/j.pcd.2021.08.014",

language = "English",

volume = "15",

pages = "899--909",

journal = "Primary Care Diabetes",

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T1 - The epidemiology, pathophysiological mechanisms, and management toward COVID-19 patients with Type 2 diabetes

T2 - a systematic review

AU - Yin, Yun

AU - Rohli, Kristen E.

AU - Shen, Pengyue

AU - Lu, Haonan

AU - Liu, Yuenan

AU - Dou, Qingyu

AU - Zhang, Lin

AU - Kong, Xiangyi

AU - Yang, Shujuan

AU - Jia, Peng

N1 - Funding Information: We thank Prof. Donna Ryan (President of the World Obesity Federation and professor Emerita at Pennington Biomedical in Baton Rouge, Louisiana, US) for the critical comments and revisions to improve the quality of this study. We also thank the International Institute of Spatial Lifecourse Epidemiology (ISLE) for the research support. Publisher Copyright: © 2021 Primary Care Diabetes Europe

PY - 2021/12

Y1 - 2021/12

N2 - This review comprehensively summarizes epidemiologic evidence of COVID-19 in patients with Type 2 diabetes, explores pathophysiological mechanisms, and integrates recommendations and guidelines for patient management. We found that diabetes was a risk factor for diagnosed infection and poor prognosis of COVID-19. Patients with diabetes may be more susceptible to adverse outcomes associated with SARS-CoV-2 infection due to impaired immune function and possible upregulation of enzymes that mediate viral invasion. The chronic inflammation caused by diabetes, coupled with the acute inflammatory reaction caused by SARS-CoV-2, results in a propensity for inflammatory storm. Patients with diabetes should be aware of their increased risk for COVID-19.

AB - This review comprehensively summarizes epidemiologic evidence of COVID-19 in patients with Type 2 diabetes, explores pathophysiological mechanisms, and integrates recommendations and guidelines for patient management. We found that diabetes was a risk factor for diagnosed infection and poor prognosis of COVID-19. Patients with diabetes may be more susceptible to adverse outcomes associated with SARS-CoV-2 infection due to impaired immune function and possible upregulation of enzymes that mediate viral invasion. The chronic inflammation caused by diabetes, coupled with the acute inflammatory reaction caused by SARS-CoV-2, results in a propensity for inflammatory storm. Patients with diabetes should be aware of their increased risk for COVID-19.

KW - COVID-19

KW - Diabetes

KW - Epidemiology

KW - Management

KW - Pathophysiological mechanism

KW - SARS-CoV-2

UR - https://www.scopus.com/pages/publications/85116022346

U2 - 10.1016/j.pcd.2021.08.014

DO - 10.1016/j.pcd.2021.08.014

M3 - Review Article

C2 - 34600859

AN - SCOPUS:85116022346

SN - 1751-9918

VL - 15

SP - 899

EP - 909

JO - Primary Care Diabetes

JF - Primary Care Diabetes

IS - 6

ER -

The epidemiology, pathophysiological mechanisms, and management toward COVID-19 patients with Type 2 diabetes: a systematic review

Abstract

UN SDGs

Keywords

Access to Document

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