The epidemiology, pathophysiological mechanisms, and management toward COVID-19 patients with Type 2 diabetes: a systematic review

Yun Yin, Kristen E. Rohli, Pengyue Shen, Haonan Lu, Yuenan Liu, Qingyu Dou, Lin Zhang, Xiangyi Kong, Shujuan Yang, Peng Jia

Research output: Contribution to journalReview ArticleResearchpeer-review

11 Citations (Scopus)


This review comprehensively summarizes epidemiologic evidence of COVID-19 in patients with Type 2 diabetes, explores pathophysiological mechanisms, and integrates recommendations and guidelines for patient management. We found that diabetes was a risk factor for diagnosed infection and poor prognosis of COVID-19. Patients with diabetes may be more susceptible to adverse outcomes associated with SARS-CoV-2 infection due to impaired immune function and possible upregulation of enzymes that mediate viral invasion. The chronic inflammation caused by diabetes, coupled with the acute inflammatory reaction caused by SARS-CoV-2, results in a propensity for inflammatory storm. Patients with diabetes should be aware of their increased risk for COVID-19.

Original languageEnglish
Pages (from-to)899-909
Number of pages11
JournalPrimary Care Diabetes
Issue number6
Publication statusPublished - Dec 2021
Externally publishedYes


  • COVID-19
  • Diabetes
  • Epidemiology
  • Management
  • Pathophysiological mechanism
  • SARS-CoV-2

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