The emerging roles of eosinophils in mucosal homeostasis

Kathleen Shah, Aline Ignacio, Kathy D. McCoy, Nicola L. Harris

Research output: Contribution to journalReview ArticleResearchpeer-review

18 Citations (Scopus)

Abstract

Eosinophils are granulocytes, typically implicated as end-stage effector cells in type-II immune responses. They are capable of producing a wide array of pre-formed molecules which render them with vast potential to influence a wide variety of processes. Nonetheless, eosinophil research has traditionally focused on their role in anti-helminthic responses and pathophysiological processes in type-II immune disorders, such as allergy and asthma, where eosinophilia is a hallmark phenotype. However, a number of key studies over the past decade have placed this restricted view of eosinophil function into question, presenting additional evidence for eosinophils as critical regulators of various homeostatic processes including immune maintenance, organ development, and tissue regeneration.

Original languageEnglish
Pages (from-to)574-583
Number of pages10
JournalMucosal Immunology
Volume13
Issue number4
DOIs
Publication statusPublished - 1 Jul 2020

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