Abstract
Nanomaterials are beginning to play an important role in the next generation of immunological assays and biosensors, with potential impacts both in research and clinical practice. In this brief review, we highlight two areas in which nanomaterials are already making new and important contributions in the past 5–10 years: firstly, in the improvement of assay and biosensor sensitivity for detection of low abundance proteins of immunological significance, and secondly, in the real-time and continuous monitoring of protein secretion from arrays of individual cells. We finish by challenging the immunology/sensing communities to work together to develop nanomaterials that can provide real-time, continuous, and sensitive molecular readouts in vivo, a lofty goal that will require significant collaborative effort.
| Original language | English |
|---|---|
| Pages (from-to) | 28-35 |
| Number of pages | 8 |
| Journal | Molecular Immunology |
| Volume | 98 |
| DOIs | |
| Publication status | Published - 1 Jun 2018 |
Keywords
- Cell array
- Cytokine
- Nanomaterials
- Plasmonic
- Sensitivity
Cite this
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The emerging role of nanomaterials in immunological sensing — a brief review. / Corrie, Simon R.; Plebanski, Magdalena.
In: Molecular Immunology, Vol. 98, 01.06.2018, p. 28-35.Research output: Contribution to journal › Review Article › Research › peer-review
TY - JOUR
T1 - The emerging role of nanomaterials in immunological sensing — a brief review
AU - Corrie, Simon R.
AU - Plebanski, Magdalena
PY - 2018/6/1
Y1 - 2018/6/1
N2 - Nanomaterials are beginning to play an important role in the next generation of immunological assays and biosensors, with potential impacts both in research and clinical practice. In this brief review, we highlight two areas in which nanomaterials are already making new and important contributions in the past 5–10 years: firstly, in the improvement of assay and biosensor sensitivity for detection of low abundance proteins of immunological significance, and secondly, in the real-time and continuous monitoring of protein secretion from arrays of individual cells. We finish by challenging the immunology/sensing communities to work together to develop nanomaterials that can provide real-time, continuous, and sensitive molecular readouts in vivo, a lofty goal that will require significant collaborative effort.
AB - Nanomaterials are beginning to play an important role in the next generation of immunological assays and biosensors, with potential impacts both in research and clinical practice. In this brief review, we highlight two areas in which nanomaterials are already making new and important contributions in the past 5–10 years: firstly, in the improvement of assay and biosensor sensitivity for detection of low abundance proteins of immunological significance, and secondly, in the real-time and continuous monitoring of protein secretion from arrays of individual cells. We finish by challenging the immunology/sensing communities to work together to develop nanomaterials that can provide real-time, continuous, and sensitive molecular readouts in vivo, a lofty goal that will require significant collaborative effort.
KW - Cell array
KW - Cytokine
KW - Nanomaterials
KW - Plasmonic
KW - Sensitivity
UR - http://www.scopus.com/inward/record.url?scp=85044531737&partnerID=8YFLogxK
U2 - 10.1016/j.molimm.2017.12.017
DO - 10.1016/j.molimm.2017.12.017
M3 - Review Article
VL - 98
SP - 28
EP - 35
JO - Molecular Immunology
JF - Molecular Immunology
SN - 0161-5890
ER -