The emerging role of nanomaterials in immunological sensing — a brief review

Simon R. Corrie; Magdalena Plebanski

doi:10.1016/j.molimm.2017.12.017

The emerging role of nanomaterials in immunological sensing — a brief review

Simon R. Corrie, Magdalena Plebanski

Research output: Contribution to journal › Review Article › Research › peer-review

11 Citations (Scopus)

Abstract

Nanomaterials are beginning to play an important role in the next generation of immunological assays and biosensors, with potential impacts both in research and clinical practice. In this brief review, we highlight two areas in which nanomaterials are already making new and important contributions in the past 5–10 years: firstly, in the improvement of assay and biosensor sensitivity for detection of low abundance proteins of immunological significance, and secondly, in the real-time and continuous monitoring of protein secretion from arrays of individual cells. We finish by challenging the immunology/sensing communities to work together to develop nanomaterials that can provide real-time, continuous, and sensitive molecular readouts in vivo, a lofty goal that will require significant collaborative effort.

Original language	English
Pages (from-to)	28-35
Number of pages	8
Journal	Molecular Immunology
Volume	98
DOIs	https://doi.org/10.1016/j.molimm.2017.12.017
Publication status	Published - 1 Jun 2018

Keywords

Cell array
Cytokine
Nanomaterials
Plasmonic
Sensitivity

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10.1016/j.molimm.2017.12.017

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abstract = "Nanomaterials are beginning to play an important role in the next generation of immunological assays and biosensors, with potential impacts both in research and clinical practice. In this brief review, we highlight two areas in which nanomaterials are already making new and important contributions in the past 5–10 years: firstly, in the improvement of assay and biosensor sensitivity for detection of low abundance proteins of immunological significance, and secondly, in the real-time and continuous monitoring of protein secretion from arrays of individual cells. We finish by challenging the immunology/sensing communities to work together to develop nanomaterials that can provide real-time, continuous, and sensitive molecular readouts in vivo, a lofty goal that will require significant collaborative effort.",

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N2 - Nanomaterials are beginning to play an important role in the next generation of immunological assays and biosensors, with potential impacts both in research and clinical practice. In this brief review, we highlight two areas in which nanomaterials are already making new and important contributions in the past 5–10 years: firstly, in the improvement of assay and biosensor sensitivity for detection of low abundance proteins of immunological significance, and secondly, in the real-time and continuous monitoring of protein secretion from arrays of individual cells. We finish by challenging the immunology/sensing communities to work together to develop nanomaterials that can provide real-time, continuous, and sensitive molecular readouts in vivo, a lofty goal that will require significant collaborative effort.

AB - Nanomaterials are beginning to play an important role in the next generation of immunological assays and biosensors, with potential impacts both in research and clinical practice. In this brief review, we highlight two areas in which nanomaterials are already making new and important contributions in the past 5–10 years: firstly, in the improvement of assay and biosensor sensitivity for detection of low abundance proteins of immunological significance, and secondly, in the real-time and continuous monitoring of protein secretion from arrays of individual cells. We finish by challenging the immunology/sensing communities to work together to develop nanomaterials that can provide real-time, continuous, and sensitive molecular readouts in vivo, a lofty goal that will require significant collaborative effort.

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KW - Cytokine

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The emerging role of nanomaterials in immunological sensing — a brief review

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Keywords

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ARC Centre of Excellence in Convergent Bio-Nano Science and Technology

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The emerging role of nanomaterials in immunological sensing — a brief review

Abstract

Keywords

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ARC Centre of Excellence in Convergent Bio-Nano Science and Technology

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