The emerging role of lipoproteins in atherogenesis: Beyond LDL cholesterol

Stephen Nicholls, Pia Lundman

Research output: Contribution to journalReview ArticleResearchpeer-review

33 Citations (Scopus)

Abstract

Low-density lipoprotein cholesterol has a well-established role in atherogenesis and the development of coronary heart disease. However, despite effective lowering of low-density lipoprotein cholesterol, many patients continue to have cardiovascular events. It has subsequently emerged that several additional dyslipidemic states promote atherogenesis. In particular, the atherogenic lipoprotein phenotype comprising an elevation of triglycerides and triglyceride-rich lipoproteins; decreased concentrations of high-density lipoprotein cholesterol; and increased small, dense low-density lipoprotein cholesterol, in addition to impaired postprandial lipemia, have been demonstrated to have profound effects on the arterial wall. As such, these factors have become important targets in the development of effective strategies to prevent atherosclerotic cardiovascular disease.

Original languageEnglish
Pages (from-to)187-195
Number of pages9
JournalSeminars in Vascular Medicine
Volume4
Issue number2
DOIs
Publication statusPublished - 1 May 2004
Externally publishedYes

Keywords

  • Atherosclerosis
  • Endothelial function
  • HDL
  • Inflammation
  • Triglycerides

Cite this