The emerging role of extracellular vesicles as biomarkers for urogenital cancers

Muhammad Nawaz, Giovanni Camussi, Hadi Valadi, Irina Nazarenko, Karin Ekström, Xiaoqin Wang, Simona Principe, Neelam Shah, Naeem M. Ashraf, Farah Fatima, Luciano Neder, Thomas Kislinger

Research output: Contribution to journalReview ArticleResearchpeer-review

162 Citations (Scopus)

Abstract

The knowledge gained from comprehensive profiling projects that aim to define the complex genomic alterations present within cancers will undoubtedly improve our ability to detect and treat those diseases, but the influence of these resources on our understanding of basic cancer biology is still to be demonstrated. Extracellular vesicles have gained considerable attention in past years, both as mediators of intercellular signalling and as potential sources for the discovery of novel cancer biomarkers. In general, research on extracellular vesicles investigates either the basic mechanism of vesicle formation and cargo incorporation, or the isolation of vesicles from available body fluids for biomarker discovery. A deeper understanding of the cargo molecules present in extracellular vesicles obtained from patients with urogenital cancers, through high-throughput proteomics or genomics approaches, will aid in the identification of novel diagnostic and prognostic biomarkers, and can potentially lead to the discovery of new therapeutic targets.

Original languageEnglish
Pages (from-to)688-701
Number of pages14
JournalNature Reviews Urology
Volume11
Issue number12
DOIs
Publication statusPublished - Dec 2014

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