The emerging picture of the mouse mammary stem cell

François Vaillant, Marie Liesse Asselin-Labat, Mark Shackleton, Geoffrey J. Lindeman, Jane E. Visvader

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

Abstract

The isolation and characterisation of mammary stem cells is an important step towards elucidating the hierarchy of epithelial cell development in the mammary gland and identifying cells that are targets of breast carcinogenesis. Mammary stem cells have recently been prospectively isolated through the identification of specific cell surface markers and in vivo transplantation into cleared fat pads. These cells were demonstrated to reconstitute an entire mammary gland comprising all mature epithelial cell types and to be capable of self-renewal on serial transplantation, thus possessing the defining features of stem cells. Notably, mouse mammary stem cells were found to share the hallmark properties of the basal subtype of breast cancer. This review will summarize the strategy used in the identification of mouse mammary stem cells and their characterisation.

Original languageEnglish
Pages (from-to)114-123
Number of pages10
JournalStem Cell Reviews
Volume3
Issue number2
DOIs
Publication statusPublished - 1 Jun 2007
Externally publishedYes

Keywords

  • In vivo repopulation
  • Integrins
  • Mammary gland
  • Multi-lineage differentiation
  • Self-renewal
  • Wnt-1

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