@article{eef92fed4e154c2297aad8ff02c339bc,
title = "The emergence of cancer sono-immunotherapy",
abstract = "Owing to its remarkable ease of use, ultrasound has recently been explored for stimulating or amplifying immune responses during cancer therapy, termed {\textquoteleft}sono-immunotherapy{\textquoteright}. Ultrasound can cause immunogenic cell death in cancer cells via thermal and nonthermal effects to regulate the tumor microenvironment, thereby priming anticancer immunity; by integrating well-designed biomaterials, novel sono-immunotherapy approaches with augmented efficacy can also be developed. Here, we review the advances in sono-immunotherapy for cancer treatment and summarize existing limitations along with potential trends. We offer emerging insights into this realm, which might prompt breakthroughs and expand its potential applications to other diseases.",
keywords = "biomaterials, biosafety, sono-immunotherapy, sonodynamic therapy, tumor microenvironment",
author = "Yuqi Yang and Yuan Cheng and Liang Cheng",
note = "Funding Information: This article was partially supported by the National Research Programs of China (2022YFB3804600), National Natural Science Foundation of China (U20A20254, 52072253), Collaborative Innovation Center of Suzhou Nano Science and Technology, Suzhou Key Laboratory of Nanotechnology and Biomedicine, a Jiangsu Natural Science Fund for Distinguished Young Scholars (BK20211544), the 111 Project, and Joint International Research Laboratory of Carbon-Based Functional Materials and Devices, Suzhou Key Laboratory of Nanotechnology and Biomedicine, and Key Laboratory of Structural Deformities in Children of Suzhou (SZS2022018). All the authors are thankful for the professional suggestions provided by Dr J. Ge from the Department of Orthopedic Surgery, the First Affiliated Hospital of Soochow University; Dr X. Zhong from the School of Public Health, Suzhou Medical College of Soochow University; Dr N. Yang, Dr L. Wang, and Mr Z. Pei from FUNSOM, Soochow University. All the authors thank the website Biorender.com for assisting in creating the illustrations. The authors declare no competing financial interest. Funding Information: This article was partially supported by the National Research Programs of China ( 2022YFB3804600 ), National Natural Science Foundation of China ( U20A20254 , 52072253 ), Collaborative Innovation Center of Suzhou Nano Science and Technology , Suzhou Key Laboratory of Nanotechnology and Biomedicine , a Jiangsu Natural Science Fund for Distinguished Young Scholars ( BK20211544 ), the 111 Project , and Joint International Research Laboratory of Carbon-Based Functional Materials and Devices , Suzhou Key Laboratory of Nanotechnology and Biomedicine , and Key Laboratory of Structural Deformities in Children of Suzhou ( SZS2022018 ). All the authors are thankful for the professional suggestions provided by Dr J. Ge from the Department of Orthopedic Surgery, the First Affiliated Hospital of Soochow University; Dr X. Zhong from the School of Public Health, Suzhou Medical College of Soochow University; Dr N. Yang, Dr Li Wang, and Mr Zifan Pei from FUNSOM, Soochow University. All the authors thank the website Biorender.com for assisting in creating the illustrations. Publisher Copyright: {\textcopyright} 2024 Elsevier Ltd",
year = "2024",
month = jul,
doi = "10.1016/j.it.2024.06.001",
language = "English",
volume = "45",
pages = "549--563",
journal = "Trends in Immunology",
issn = "1471-4981",
publisher = "Cell Press",
number = "7",
}
