The efficacy of the newer antiepileptic drugs in controlling seizures in pregnancy

Frank J E Vajda; Terence O'Brien; Cecilie Lander; Janet Graham; Mervyn Eadie

doi:10.1111/epi.12711

The efficacy of the newer antiepileptic drugs in controlling seizures in pregnancy

Frank J E Vajda, Terence O'Brien, Cecilie Lander, Janet Graham, Mervyn Eadie

Research output: Contribution to journal › Article › Research › peer-review

38 Citations (Scopus)

Abstract

Summary Objectives To assess the effectiveness of the newer antiepileptic drugs (AEDs) - in particular lamotrigine, topiramate, and levetiracetam - in controlling epileptic seizures in pregnant women. Methods Analysis of data in the Australian Register of Antiepileptic Drugs in Pregnancy concerning seizure control in 1,534 pregnancies in women with AED-treated epilepsies. Results In AED monotherapy (1,111 pregnancies), use of levetiracetam in pregnancies in the Australian Register was associated with levels of seizure control similar to those that applied for the major older AEDs carbamazepine and valproate, but with levels of seizure control superior to those associated with use of lamotrigine and topiramate. Significance Levetiracetam shows promise as a satisfactory drug for controlling seizures in pregnancy.

Original language	English
Pages (from-to)	1229-1234
Number of pages	6
Journal	Epilepsia
Volume	55
Issue number	8
DOIs	https://doi.org/10.1111/epi.12711
Publication status	Published - 2014
Externally published	Yes

Keywords

Antiepileptic drugs
Lamotrigine
Levetiracetam
Pregnancy
Seizures
Topiramate

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10.1111/epi.12711

240129977-oaFinal published version, 266 KB

Cite this

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AU - O'Brien, Terence

AU - Lander, Cecilie

AU - Graham, Janet

AU - Eadie, Mervyn

PY - 2014

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The efficacy of the newer antiepileptic drugs in controlling seizures in pregnancy

Abstract

Keywords

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