The effects of total sleep deprivation on cerebral responses to cognitive performance

Sean P.A. Drummond, Gregory G. Brown

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218 Citations (Scopus)

Abstract

We review the findings from a study utilizing functional magnetic resonance imaging (FMRI) to examine the effects of total sleep deprivation (TSD) on verbal learning, arithmetic, and divided attention. For verbal learning and divided attention, TSD was associated with increased activation in the bilateral prefrontal cortex and parietal lobes. Increased sleepiness after TSD and lower levels of memory impairment were correlated with increased activation in specific regions of the prefrontal cortex and parietal lobes, respectively. The arithmetic task led tosignificantly decreased activation in the bilateral prefrontal cortex and parietal lobes. Based on this and other data, we hypothesize an adaptive cerebral response during cognitive performance following TSD with the specific pattern of adaptation depending on the specific cognitive processes performed. We discuss the need to test the hypothesis in a variety of ways.

Original languageEnglish
Pages (from-to)S68-S73
JournalNeuropsychopharmacology
Volume25
Issue number5
DOIs
Publication statusPublished - 1 Jan 2001
Externally publishedYes

Keywords

  • Arithmetic
  • Divided attention
  • FMRI
  • Parietal lobes
  • Prefrontal cortex
  • Sleep deprivation
  • Verbal learning

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