TY - JOUR
T1 - The effects of synbiotic supplementation on insulin resistance/sensitivity, lipid profile and total antioxidant capacity in women with gestational diabetes mellitus
T2 - A randomized double blind placebo controlled clinical trial
AU - Nabhani, Zohoor
AU - Hezaveh, Seyed Jamal Ghaemmaghami
AU - Razmpoosh, Elham
AU - Asghari-Jafarabadi, Mohammad
AU - Gargari, Bahram Pourghassem
N1 - Funding Information:
We thank all of the patients for their participation in this study, and Tabriz University of Medical Sciences , Tabriz, Iran. and Nutrition Research Center for funding this trial. We are also thankful to ZistTakhmir Company, Tehran, Iran, for providing LactoFem multispecies probiotic supplements for the present study.
Funding Information:
We thank all of the patients for their participation in this study, and Tabriz University of Medical Sciences, Tabriz, Iran. and Nutrition Research Center for funding this trial. We are also thankful to ZistTakhmir Company, Tehran, Iran, for providing LactoFem multispecies probiotic supplements for the present study.
Publisher Copyright:
© 2018 Elsevier B.V.
PY - 2018/4
Y1 - 2018/4
N2 - Aims: The role of gut microbiota in the management of diabetes is shown. In this randomized clinical trial we assessed the effects of synbiotic supplementation on insulin, lipid profile and antioxidative status among women with gestational diabetes mellitus (GDM). Methods: Ninety pregnant women with GDM were randomly assigned into two groups to receive either a daily synbiotic capsule – consisting of L. acidophilus, L. plantarum, L. fermentum, L. gasseri (1.5–7.0 × 109–10 CFU/g) – with fructooligosaccharide (38.5 mg), or placebo for 6 weeks. Fasting plasma glucose (FPG), insulin, homeostasis model assessment-insulin resistance (HOMA-IR), quantitative insulin sensitivity check index (QUICKI), high- and low density lipoprotein cholesterol (HDL-C, LDL-C), total cholesterol (TC), triglycerides (TG), total antioxidant capacity (TAC), and systolic and diastolic blood pressure (SBP, DSP) were assessed before and after the intervention. Results: No significant changes in FPG, insulin resistance/sensitivity, lipid profile and TAC indices were seen in synbiotic group compared to the placebo one (p > 0.05). Significant within group increases for HDL-C and TAC levels in synbiotic group were observed (p < 0.05). LDL-C showed significant increment in the placebo group compared to the baseline of the study (6.9 mg/dL, p < 0.05). Between group comparison showed significant decrease in SBP and DBP in synbiotic group compared to placebo (−2.5 vs. 8.6 mmHg, and −1.8 vs. 2.1 mmHg, p < 0.05). Conclusions: The results showed that, in women with GDM, synbiotic supplementation had no effect on FPG and insulin resistance/sensitivity indices. Lipid profile and TAC status may be affected by synbiotic supplementation. Synbiotic is effective in reducing of blood pressure in women with GDM.
AB - Aims: The role of gut microbiota in the management of diabetes is shown. In this randomized clinical trial we assessed the effects of synbiotic supplementation on insulin, lipid profile and antioxidative status among women with gestational diabetes mellitus (GDM). Methods: Ninety pregnant women with GDM were randomly assigned into two groups to receive either a daily synbiotic capsule – consisting of L. acidophilus, L. plantarum, L. fermentum, L. gasseri (1.5–7.0 × 109–10 CFU/g) – with fructooligosaccharide (38.5 mg), or placebo for 6 weeks. Fasting plasma glucose (FPG), insulin, homeostasis model assessment-insulin resistance (HOMA-IR), quantitative insulin sensitivity check index (QUICKI), high- and low density lipoprotein cholesterol (HDL-C, LDL-C), total cholesterol (TC), triglycerides (TG), total antioxidant capacity (TAC), and systolic and diastolic blood pressure (SBP, DSP) were assessed before and after the intervention. Results: No significant changes in FPG, insulin resistance/sensitivity, lipid profile and TAC indices were seen in synbiotic group compared to the placebo one (p > 0.05). Significant within group increases for HDL-C and TAC levels in synbiotic group were observed (p < 0.05). LDL-C showed significant increment in the placebo group compared to the baseline of the study (6.9 mg/dL, p < 0.05). Between group comparison showed significant decrease in SBP and DBP in synbiotic group compared to placebo (−2.5 vs. 8.6 mmHg, and −1.8 vs. 2.1 mmHg, p < 0.05). Conclusions: The results showed that, in women with GDM, synbiotic supplementation had no effect on FPG and insulin resistance/sensitivity indices. Lipid profile and TAC status may be affected by synbiotic supplementation. Synbiotic is effective in reducing of blood pressure in women with GDM.
KW - Blood pressure
KW - Cholesterol HDL
KW - Diabetes
KW - Gestational
KW - Insulin
KW - Synbiotic
UR - http://www.scopus.com/inward/record.url?scp=85042375719&partnerID=8YFLogxK
U2 - 10.1016/j.diabres.2018.02.008
DO - 10.1016/j.diabres.2018.02.008
M3 - Article
C2 - 29432772
AN - SCOPUS:85042375719
SN - 0168-8227
VL - 138
SP - 149
EP - 157
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
ER -
