The effects of sex hormonal fluctuations during menstrual cycle on cortical excitability and manual dexterity (a pilot study)

Maryam Zoghi, Bita Vaseghi, A Bastani, Shapour Jaberzadeh, Mary Pauline Galea

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    Aim: To investigate whether hormonal fluctuations during the menstrual cycle affect corticospinal excitability, intracortical inhibition (ICI) or facilitation (ICF) in primary motor cortex, and also whether the hormonal fluctuations have any effect on manual dexterity in neurologically intact women. Materials and Methods: Twenty volunteers (10 Female, 10 Male) were included in this study. The levels of progesterone and estradiol were measured from saliva during the women?s menstrual follicular, ovulation and mid-luteal phases. Motor evoked potentials were recorded from the right first dorsal interosseous muscle. Single and paired-pulse Transcranial Magnetic Stimulation (TMS) were delivered in a block of 20 stimuli. With paired-pulse technique, 3ms and 10ms inter-stimulus intervals were used to assess ICI and ICF, respectively. The Grooved Pegboard Test (GPT) was completed in each session before the TMS assessments. Male participants were tested at similar time intervals as female participants.
    Original languageEnglish
    Article numbere0136081
    Number of pages14
    JournalPLoS ONE
    Publication statusPublished - 2015

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