The Effects of Neonatal Hyperoxia on Lung Development

Foula Sozo, Megan O'Reilly

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review


Advances in neonatal care have enabled infants to survive extreme prematurity. Supplemental oxygen therapy is usually required and can lead to life-long alterations in the lungs as a result of oxidative stress and inflammation. The conducting airways, gas-exchanging tissue, and the pulmonary vasculature can all be affected by neonatal exposure to hyperoxia and can contribute to the increased risk of persistent pulmonary dysfunction. Ongoing inflammation may also increase the risk of respiratory infection and asthma later in life. Improvements in long-term outcomes in pulmonary health are likely to result from changes in clinical practice that target minimizing hyperoxia exposure, as well as therapies aimed at preventing and/or repairing neonatal lung injury. As supplemental oxygen is currently unavoidable in the care of very preterm infants, future studies should aim to determine the most effective methods for reducing lung injury in infancy and for identifying long-term effects on the lungs.
Original languageEnglish
Title of host publicationThe Lung
Subtitle of host publicationDevelopment, Aging and the Environment
EditorsRichard Harding, Kent E Pinkerton
Place of PublicationLondon UK
PublisherAcademic Press
Number of pages19
ISBN (Print)9780127999418
Publication statusPublished - 2015

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