The effects of hydroxychloroquine on endothelial dysfunction

Rahana Rahman, Padma Murthi, Harmeet Singh, Seshini Gurusinghe, Joanne C. Mockler, Rebecca Lim, Euan M. Wallace

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Abstract

Hydroxychloroquine is an anti-malarial drug which, due to its anti-inflammatory and immunomodulatory effects, is widely used for the treatment of autoimmune diseases. In a model of systemic lupus erythematosus hydroxychloroquine has been shown to exert protective endothelial effects. In this study, we aimed to investigate whether hydroxychloroquine was endothelial protective in an in vitro model of TNF-α and preeclamptic serum induced dysfunction. We showed that hydroxychloroquine significantly reduced the production of TNF-α and preeclamptic serum induced endothelin-1 (ET-1). Hydroxychloroquine also significantly mitigated TNF-α induced impairment of angiogenesis. These findings support the further assessment of hydroxychloroquine as an adjuvant therapy in preeclampsia.

Original languageEnglish
Pages (from-to)259-262
Number of pages4
JournalPregnancy Hypertension
Volume6
Issue number4
DOIs
Publication statusPublished - 1 Oct 2016

Keywords

  • Endothelial dysfunction
  • Endothelin-1
  • Hydroxychloroquine
  • Preeclampsia
  • Preeclamptic serum
  • TNF-α

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