The effects of gender on grey matter abnormalities in major psychoses: a comparative voxelwise meta-analysis of schizophrenia and bipolar disorder

Emre Bora, A. Fornito, Murat Yucel, Christos Pantelis

Research output: Contribution to journalArticleResearchpeer-review

67 Citations (Scopus)

Abstract

Background Recent evidence from genetic and familial studies revitalized the debate concerning the validity of the distinction between schizophrenia and bipolar disorder. Comparing brain imaging findings is an important avenue to examine similarities and differences and, therefore, the validity of the distinction between these conditions. However, in contrast to bipolar disorder, most patient samples in studies of schizophrenia are predominantly male. This a limiting factor for comparing schizophrenia and bipolar disorder since male gender is associated with more severe neurodevelopmental abnormalities, negative symptoms and cognitive deficits in schizophrenia.
Original languageEnglish
Pages (from-to)295-307
Number of pages13
JournalPsychological Medicine
Volume42
Issue number2
DOIs
Publication statusPublished - Feb 2012
Externally publishedYes

Keywords

  • bipolar disorder
  • grey matter
  • MRI
  • schizophrenia
  • voxel based morphometry

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