The Effects of Food on the Oral Bioavailability of Doxazosin in Hypertensive Subjects

E. L. Conway, J. J. McNeil, J. Hurley, G. P. Jackman, H. Krum, L. G. Howes, W. J. Louis

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Abstract

The bioavailability of and pharmacodynamic responses to doxazosin, administered with and without food, were examined in a crossover study in 12 hypertensive subjects. The administration of doxazosin with food delayed its absorption by approximately 1 hour, reduced the maximum (peak) plasma drug concentration after single dose administration (Cmax) by 18%, and reduced the area under the plasma concentration-time curve (AUC) by 12%; however, these effects were not statistically significant. The acute fall in blood pressure following doxazosin administration was not significantly affected by food; however, there was a trend towards a lower incidence of complaints in this group. The effect of coadministration of food on the pharmacokinetic and pharmacodynamic responses to doxazosin are unlikely to be of clinical significance.

Original languageEnglish
Pages (from-to)90-95
Number of pages6
JournalDrug Investigation
Volume6
Issue number2
DOIs
Publication statusPublished - 1 Jan 1993

Cite this

Conway, E. L., McNeil, J. J., Hurley, J., Jackman, G. P., Krum, H., Howes, L. G., & Louis, W. J. (1993). The Effects of Food on the Oral Bioavailability of Doxazosin in Hypertensive Subjects. Drug Investigation, 6(2), 90-95. https://doi.org/10.1007/BF03258458