The effects of dietary weight loss with or without exercise training on liver enzymes in obese metabolic syndrome subjects

Nora Straznicky, Elisabeth Lambert, Mariee Grima, Nina Eikelis, Paul Nestel, Tye Dawood, Markus Schlaich, Kazuko Masuo, Reena Chopra, Carolina Sari, John Dixon, Alan Tilbrook, Gavin Lambert

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Abstract

Aims: Insulin resistance and visceral adiposity are predisposing factors for fatty liver disease. The main objectives of this study were 1) to compare the effects of caloric restriction alone (CR) or together with moderate-intensity aerobic exercise training (CR+EX) on liver enzymes, a surrogate marker of liver injury, in obese metabolic syndrome (MetS) subjects and 2) to identify anthropometric, metabolic, cardiovascular and dietary predictors of changes in liver enzymes. Methods: Sedentary men and women (n=63), aged 55 + 6 (SD) years with body mass index 32.7 + 4.1 kg/m(2) and confirmed MetS, were randomized to 12-weeks CR, CR+EX or no treatment (Control). Results: Weight loss averaged 7.6 in the CR and 9.1 in the CR+EX group (time effect, P
Original languageEnglish
Pages (from-to)139 - 148
Number of pages10
JournalDiabetes, Obesity and Metabolism
Volume14
Issue number2
DOIs
Publication statusPublished - 2012

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