TY - JOUR
T1 - The effects of B‐HT 920 and St 91 on venous haemodynamics in cats
AU - WIDDOP, ROBERT E.
PY - 1989/1/1
Y1 - 1989/1/1
N2 - Abstract— The present study reports the effects of 2‐amino‐6‐allyl‐5,6,7,8‐tetrahydro‐4H‐thiazolo‐[4,5‐d]azepin dihydrochloride (B‐HT 920) and 2‐(2,6‐diethylphenylimino)‐2‐imidazolidine hydrochloride (St 91) in autoperfused cat hindquarters since we have previously shown that clonidine lowered blood pressure, heart rate and vena cava blood flow (VCBF) but not hindquarters perfusion pressure, indicating a selective venodilator action of this drug (Bentley et al 1986). It was found that intravenous (i.v.) and intracisternal (i.c.m.) administration of B‐HT 920 caused essentially identical effects to those of Clonidine. St 91, given i.c.m. lowered blood pressure and VCBF but not perfusion pressure, while i.v. St 91 had little effect on these variables. Thus, parallel changes in blood pressure and VCBF occurred using both drugs, suggesting that these centrally‐acting clonidine‐like drugs also caused selective venodilatation. 1989 Royal Pharmaceutical Society of Great Britain
AB - Abstract— The present study reports the effects of 2‐amino‐6‐allyl‐5,6,7,8‐tetrahydro‐4H‐thiazolo‐[4,5‐d]azepin dihydrochloride (B‐HT 920) and 2‐(2,6‐diethylphenylimino)‐2‐imidazolidine hydrochloride (St 91) in autoperfused cat hindquarters since we have previously shown that clonidine lowered blood pressure, heart rate and vena cava blood flow (VCBF) but not hindquarters perfusion pressure, indicating a selective venodilator action of this drug (Bentley et al 1986). It was found that intravenous (i.v.) and intracisternal (i.c.m.) administration of B‐HT 920 caused essentially identical effects to those of Clonidine. St 91, given i.c.m. lowered blood pressure and VCBF but not perfusion pressure, while i.v. St 91 had little effect on these variables. Thus, parallel changes in blood pressure and VCBF occurred using both drugs, suggesting that these centrally‐acting clonidine‐like drugs also caused selective venodilatation. 1989 Royal Pharmaceutical Society of Great Britain
UR - http://www.scopus.com/inward/record.url?scp=0024537244&partnerID=8YFLogxK
U2 - 10.1111/j.2042-7158.1989.tb06330.x
DO - 10.1111/j.2042-7158.1989.tb06330.x
M3 - Article
C2 - 2565967
AN - SCOPUS:0024537244
VL - 41
SP - 55
EP - 56
JO - Journal of Pharmacy and Pharmacology
JF - Journal of Pharmacy and Pharmacology
SN - 0022-3573
IS - 1
ER -