TY - JOUR
T1 - The effects of anodal tDCS on pain reduction in people with knee osteoarthritis
T2 - A systematic review and meta-analysis
AU - Dissanayaka, Thusharika
AU - Nakandala, Piumi
AU - Malwanage, Kavinda
AU - Hill, Aron T.
AU - Ashthree, Deborah N.
AU - Lane, Melissa M.
AU - Travicia, Nikolaj
AU - Gamage, Elizabeth
AU - Marx, Wolfgang
AU - Jaberzadeh, Shapour
N1 - Funding Information:
No financial support was received for this study.
Publisher Copyright:
© 2023 The Author(s)
PY - 2023/12
Y1 - 2023/12
N2 - Objectives: To synthesise the literature on the efficacy of primary motor cortex anodal transcranial direct current stimulation (M1-a-tDCS), as a standalone or priming technique, for pain reduction in people with knee osteoarthritis (KOA). Methods: The systematic literature search was conducted in MEDLINE, CINAHL, Embase and CENTRAL according to PRISMA statement. Results: Fourteen studies involving 740 people with KOA were included. In the meta-analysis, six studies compared a-tDCS alone with sham stimulation, and five studies compared a-tDCS combined with other methods with sham stimulation. We found positive effect of a-tDCS alone on pain in KOA (standard mean difference (SMD) −0.52; 95% CI, −0.78 to −0.25; P=0.001; I2 = 69%). Further, a-tDCS with other treatments showed positive effect (SMD −1.23; 95% CI, −1.59 to −0.88; P<0.001; I2 = 48%) on pain in people with KOA. This evidence showed low certainty due to a high risk of bias and imprecision. Discussion and Conclusion: A-tDCS could be considered as standalone and an adjunct treatment for pain reduction in people with KOA. Future randomised studies should address quality issues, including small sample size, to enhance the overall certainty of the findings. Significance: A-tDCS can be used as a standalone and adjunct treatment for KOA.
AB - Objectives: To synthesise the literature on the efficacy of primary motor cortex anodal transcranial direct current stimulation (M1-a-tDCS), as a standalone or priming technique, for pain reduction in people with knee osteoarthritis (KOA). Methods: The systematic literature search was conducted in MEDLINE, CINAHL, Embase and CENTRAL according to PRISMA statement. Results: Fourteen studies involving 740 people with KOA were included. In the meta-analysis, six studies compared a-tDCS alone with sham stimulation, and five studies compared a-tDCS combined with other methods with sham stimulation. We found positive effect of a-tDCS alone on pain in KOA (standard mean difference (SMD) −0.52; 95% CI, −0.78 to −0.25; P=0.001; I2 = 69%). Further, a-tDCS with other treatments showed positive effect (SMD −1.23; 95% CI, −1.59 to −0.88; P<0.001; I2 = 48%) on pain in people with KOA. This evidence showed low certainty due to a high risk of bias and imprecision. Discussion and Conclusion: A-tDCS could be considered as standalone and an adjunct treatment for pain reduction in people with KOA. Future randomised studies should address quality issues, including small sample size, to enhance the overall certainty of the findings. Significance: A-tDCS can be used as a standalone and adjunct treatment for KOA.
KW - Knee
KW - Osteoarthritis
KW - Pain
KW - tDCS
KW - Transcranial direct current stimulation
UR - http://www.scopus.com/inward/record.url?scp=85177219431&partnerID=8YFLogxK
U2 - 10.1016/j.neucli.2023.102921
DO - 10.1016/j.neucli.2023.102921
M3 - Review Article
C2 - 37984240
AN - SCOPUS:85177219431
SN - 0987-7053
VL - 53
JO - Neurophysiologie Clinique
JF - Neurophysiologie Clinique
IS - 6
M1 - 102921
ER -