The effects of a muscarinic receptor 1 gene variant on executive and non-executive cognition in schizophrenia spectrum disorders

Sean P. Carruthers, Vanessa Cropley, Chad Bousman, Ian P. Everall, Erica Neill, Christos Pantelis, Philip J. Sumner, Australian Schizophrenia Research Bank, Eric J. Tan, Kiymet Bozaoglu, Elizabeth H.X. Thomas, Tamsyn E. Van Rheenen, Caroline T. Gurvich, Susan L. Rossell

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Abstract

Individuals with schizophrenia who are homozygous at the c.267C > A (rs2067477) single nucleotide polymorphism within the muscarinic M1 receptor gene have been reported to perform less well on the Wisconsin Card Sorting Test (WCST). We investigated if rs2067477 genotype variation influenced WCST performance and non-executive cognition cross-diagnostically in a sample of 147 schizophrenia spectrum participants (SSD) and 294 healthy controls. We were unable to detect any significant differences in executive and non-executive cognitive performance across genotype. A broader genetic focus should be considered when investigating the association between the muscarinic system and cognition in SSD.

Original languageEnglish
Pages (from-to)178-180
Number of pages3
JournalPsychiatry Research
Volume273
DOIs
Publication statusPublished - 1 Mar 2019

Keywords

  • Cognitive flexibility
  • Schizophrenia spectrum disorder
  • Wisconsin Card Sorting Test

Cite this

Carruthers, S. P., Cropley, V., Bousman, C., Everall, I. P., Neill, E., Pantelis, C., Sumner, P. J., Australian Schizophrenia Research Bank, Tan, E. J., Bozaoglu, K., Thomas, E. H. X., Van Rheenen, T. E., Gurvich, C. T., & Rossell, S. L. (2019). The effects of a muscarinic receptor 1 gene variant on executive and non-executive cognition in schizophrenia spectrum disorders. Psychiatry Research, 273, 178-180. https://doi.org/10.1016/j.psychres.2019.01.032