The effect of surgical weight loss on obstructive sleep apnoea: A systematic review and meta-analysis

Ai-Ming Wong, Hayley N. Barnes, Simon A. Joosten, Shane A. Landry, Eli Dabscheck, Darren R. Mansfield, Shyamali C. Dharmage, Chamara V. Senaratna, Bradley A. Edwards, Garun S. Hamilton

Research output: Contribution to journalReview ArticleResearchpeer-review

16 Citations (Scopus)

Abstract

This review aimed to examine the relationship between surgical weight loss and obstructive sleep apnoea (OSA) severity (i.e., apnoea-hypopnoea index [AHI]), and how this relationship is altered by the various respiratory events scoring (RES) criteria used to derive the AHI. A systematic search of the literature was performed up to December 2017. Before-and-after studies were considered due to a paucity of randomised controlled trials (RCTs) available to be reviewed in isolation. Primary outcomes included pre- and post-surgery AHI and body mass index (BMI). Secondary outcomes included sleep study type and RES criteria. Meta-analysis was undertaken where possible. Overall, surgical weight loss resulted in reduction of BMI and AHI, however, OSA persisted at follow-up in the majority of subjects. There was high between-study heterogeneity which was largely attributable to baseline AHI and duration of follow-up when analysed using meta-regression. There was insufficient data to evaluate the impact of different RES criteria on OSA severity. Therefore, more RCTs are needed to verify these findings given the high degree of heterogeneity and future studies are strongly encouraged to report the RES criteria used to enable fair and uniform comparisons of the impact of any intervention on OSA severity.

Original languageEnglish
Pages (from-to)85-99
Number of pages15
JournalSleep Medicine Reviews
Volume42
DOIs
Publication statusPublished - Dec 2018

Keywords

  • Bariatric surgery
  • Obstructive sleep apnoea
  • Sleep disordered breathing
  • Surgical weight loss

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