The effect of sensory nerve stimulation on sensory nerve function in people with peripheral neuropathy associated with diabetes

Zeinab Khalil, Rajna Ogrin, Peteris J Darzins

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    OBJECTIVE: To assess the effect of sensory nerve stimulation in older people with peripheral neuropathy associated with diabetes (DPN). MATERIALS AND METHODS: A randomized, placebo controlled, double blind trial was used to assess the effect of 12 weeks of low frequency sensory nerve stimulation (LF-SNS) in the lower limb [International Patent Application No. PCT/AU2004/001079: nerve function and tissue healing (Z. Khalil)]. Response to capsaicin, basal microvascular blood flow, electric cutaneous threshold and oxygen tension were assessed pre- and post-treatment and between limbs. PARTICIPANTS: People 55 years of age or older diagnosed with DPN: 35 active and 31 placebo participants. RESULTS: Between groups comparisons: no significant differences occurred between stimulation groups. Within subject comparisons: in the active LF-SNS group, comparing stimulated to contralateral legs, there were significant increases in size of capsaicin flare [t(1,33)=3.65, p
    Original languageEnglish
    Pages (from-to)743 - 748
    Number of pages6
    JournalNeurological Research
    Issue number7
    Publication statusPublished - 2007

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