The effect of preexisting medical comorbidities on the preeclamptic phenotype: a retrospective cohort study

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Objective:To compare the effect of comorbidities on the phenotype and outcomes of preeclampsia. Methods: A matched retrospective cohort study of women delivering at a tertiary maternity center following a diagnosis of preeclampsia. We collected data on signs and symptoms, biochemical markers, and maternal and perinatal outcomes. Results:We studied 474 women; 158 women with and 316 without comorbidities. Compared to women without comorbidities, women with comorbidities delivered earlier. They suffered fewer maternal but more neonatal complications. Conclusion: Women with comorbidities receive earlier intervention than women without comorbidities, which may lead to fewer maternal complications but worse neonatal outcomes.

Original languageEnglish
Pages (from-to)336-345
Number of pages10
JournalHypertension in Pregnancy
Issue number4
Publication statusPublished - Oct 2021


  • angiogenic
  • comorbidities
  • complications
  • hypertension
  • Preeclampsia

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