The effect of poloxamer-407 on liposome stability and targeting to bone marrow: comparison with polystyrene microspheres

S. M. Moghimi; C. J.H. Porter; L. Illum; S. S. Davis

doi:10.1016/0378-5173(91)90134-A

The effect of poloxamer-407 on liposome stability and targeting to bone marrow: comparison with polystyrene microspheres

S. M. Moghimi, C. J.H. Porter, L. Illum, S. S. Davis

Research output: Contribution to journal › Article › Research › peer-review

54 Citations (Scopus)

Abstract

In accordance with our previous studies in the rabbit (Ilium L. and Davis S.S., Life Sci., 40 (1987) 1553-1560), coating of model polystyrene microspheres (70 nm in size) with poloxamer-407 was found to prevent their hepatic sequestration and to redirect a significant proportion of intravenously injected particles to the bone marrow in rats. In contrast, preincubation of a stable and 'solid' small unilamellar liposome preparation (DSPC/Chol/DCP in a molar ratio of 7: 7:1) with poloxamer-407 provided no evidence of poloxamer penetration or adsorption onto the vesicles, as determined by photon correlation spectroscopy and laser doppler anemometry. Further, no significant difference on biodistribution of poloxamer-preincubated liposomes was observed in comparison to control vesicles following intravenous administration into rats.

Original language	English
Pages (from-to)	121-126
Number of pages	6
Journal	International Journal of Pharmaceutics
Volume	68
Issue number	1-3
DOIs	https://doi.org/10.1016/0378-5173(91)90134-A
Publication status	Published - 1 Feb 1991
Externally published	Yes

Keywords

Bone marrow
Liposome
Photon correlation spectroscopy
Poloxamer
Reticuloendothelial system

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10.1016/0378-5173(91)90134-A

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title = "The effect of poloxamer-407 on liposome stability and targeting to bone marrow: comparison with polystyrene microspheres",

abstract = "In accordance with our previous studies in the rabbit (Ilium L. and Davis S.S., Life Sci., 40 (1987) 1553-1560), coating of model polystyrene microspheres (70 nm in size) with poloxamer-407 was found to prevent their hepatic sequestration and to redirect a significant proportion of intravenously injected particles to the bone marrow in rats. In contrast, preincubation of a stable and 'solid' small unilamellar liposome preparation (DSPC/Chol/DCP in a molar ratio of 7: 7:1) with poloxamer-407 provided no evidence of poloxamer penetration or adsorption onto the vesicles, as determined by photon correlation spectroscopy and laser doppler anemometry. Further, no significant difference on biodistribution of poloxamer-preincubated liposomes was observed in comparison to control vesicles following intravenous administration into rats.",

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T2 - comparison with polystyrene microspheres

AU - Moghimi, S. M.

AU - Porter, C. J.H.

AU - Illum, L.

AU - Davis, S. S.

PY - 1991/2/1

Y1 - 1991/2/1

N2 - In accordance with our previous studies in the rabbit (Ilium L. and Davis S.S., Life Sci., 40 (1987) 1553-1560), coating of model polystyrene microspheres (70 nm in size) with poloxamer-407 was found to prevent their hepatic sequestration and to redirect a significant proportion of intravenously injected particles to the bone marrow in rats. In contrast, preincubation of a stable and 'solid' small unilamellar liposome preparation (DSPC/Chol/DCP in a molar ratio of 7: 7:1) with poloxamer-407 provided no evidence of poloxamer penetration or adsorption onto the vesicles, as determined by photon correlation spectroscopy and laser doppler anemometry. Further, no significant difference on biodistribution of poloxamer-preincubated liposomes was observed in comparison to control vesicles following intravenous administration into rats.

AB - In accordance with our previous studies in the rabbit (Ilium L. and Davis S.S., Life Sci., 40 (1987) 1553-1560), coating of model polystyrene microspheres (70 nm in size) with poloxamer-407 was found to prevent their hepatic sequestration and to redirect a significant proportion of intravenously injected particles to the bone marrow in rats. In contrast, preincubation of a stable and 'solid' small unilamellar liposome preparation (DSPC/Chol/DCP in a molar ratio of 7: 7:1) with poloxamer-407 provided no evidence of poloxamer penetration or adsorption onto the vesicles, as determined by photon correlation spectroscopy and laser doppler anemometry. Further, no significant difference on biodistribution of poloxamer-preincubated liposomes was observed in comparison to control vesicles following intravenous administration into rats.

KW - Bone marrow

KW - Liposome

KW - Photon correlation spectroscopy

KW - Poloxamer

KW - Reticuloendothelial system

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ER -

The effect of poloxamer-407 on liposome stability and targeting to bone marrow: comparison with polystyrene microspheres

Abstract

Keywords

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