The effect of poloxamer-407 on liposome stability and targeting to bone marrow: comparison with polystyrene microspheres

S. M. Moghimi, C. J.H. Porter, L. Illum, S. S. Davis

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Abstract

In accordance with our previous studies in the rabbit (Ilium L. and Davis S.S., Life Sci., 40 (1987) 1553-1560), coating of model polystyrene microspheres (70 nm in size) with poloxamer-407 was found to prevent their hepatic sequestration and to redirect a significant proportion of intravenously injected particles to the bone marrow in rats. In contrast, preincubation of a stable and 'solid' small unilamellar liposome preparation (DSPC/Chol/DCP in a molar ratio of 7: 7:1) with poloxamer-407 provided no evidence of poloxamer penetration or adsorption onto the vesicles, as determined by photon correlation spectroscopy and laser doppler anemometry. Further, no significant difference on biodistribution of poloxamer-preincubated liposomes was observed in comparison to control vesicles following intravenous administration into rats.

Original languageEnglish
Pages (from-to)121-126
Number of pages6
JournalInternational Journal of Pharmaceutics
Volume68
Issue number1-3
DOIs
Publication statusPublished - 1 Feb 1991
Externally publishedYes

Keywords

  • Bone marrow
  • Liposome
  • Photon correlation spectroscopy
  • Poloxamer
  • Reticuloendothelial system

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