The effect of oxygen content during an initial sustained inflation on heart rate in asphyxiated near-term lambs

Kristina Sobotka; Tracey Ong; Graeme Polglase; Kelly Jane Crossley; Timothy James Murugesan Moss; Stuart Brian Hooper

doi:10.1136/archdischild-2014-307319

The effect of oxygen content during an initial sustained inflation on heart rate in asphyxiated near-term lambs

Kristina Sobotka
, Tracey Ong
, Graeme Polglase
, Kelly Jane Crossley
, Timothy James Murugesan Moss
, Stuart Brian Hooper

Research output: Contribution to journal › Article › Research › peer-review

15 Citations (Scopus)

Abstract

OBJECTIVE: At birth, an initial sustained inflation (SI) uniformly aerates the lungs, increases arterial oxygenation and rapidly improves circulatory recovery in asphyxiated newborns. We hypothesised that lung aeration, in the absence of an increase in arterial oxygenation, can increase heart rate (HR) in asphyxiated near-term lambs. INTERVENTIONS: Lambs were delivered and instrumented at 139+/-2 days of gestation. Asphyxia was induced by umbilical cord clamping and then delaying the onset of ventilation until mean carotid arterial pressures (CAPs) had decreased

Original language	English
Pages (from-to)	337 - 343
Number of pages	7
Journal	Archives of Disease in Childhood: Fetal and Neonatal Edition
Volume	100
Issue number	4
DOIs	https://doi.org/10.1136/archdischild-2014-307319
Publication status	Published - 2015

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10.1136/archdischild-2014-307319

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title = "The effect of oxygen content during an initial sustained inflation on heart rate in asphyxiated near-term lambs",

abstract = "OBJECTIVE: At birth, an initial sustained inflation (SI) uniformly aerates the lungs, increases arterial oxygenation and rapidly improves circulatory recovery in asphyxiated newborns. We hypothesised that lung aeration, in the absence of an increase in arterial oxygenation, can increase heart rate (HR) in asphyxiated near-term lambs. INTERVENTIONS: Lambs were delivered and instrumented at 139+/-2 days of gestation. Asphyxia was induced by umbilical cord clamping and then delaying the onset of ventilation until mean carotid arterial pressures (CAPs) had decreased",

author = "Kristina Sobotka and Tracey Ong and Graeme Polglase and Crossley, \{Kelly Jane\} and Moss, \{Timothy James Murugesan\} and Hooper, \{Stuart Brian\}",

year = "2015",

doi = "10.1136/archdischild-2014-307319",

language = "English",

volume = "100",

pages = "337 -- 343",

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issn = "1359-2998",

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T1 - The effect of oxygen content during an initial sustained inflation on heart rate in asphyxiated near-term lambs

AU - Sobotka, Kristina

AU - Ong, Tracey

AU - Polglase, Graeme

AU - Crossley, Kelly Jane

AU - Moss, Timothy James Murugesan

AU - Hooper, Stuart Brian

PY - 2015

Y1 - 2015

N2 - OBJECTIVE: At birth, an initial sustained inflation (SI) uniformly aerates the lungs, increases arterial oxygenation and rapidly improves circulatory recovery in asphyxiated newborns. We hypothesised that lung aeration, in the absence of an increase in arterial oxygenation, can increase heart rate (HR) in asphyxiated near-term lambs. INTERVENTIONS: Lambs were delivered and instrumented at 139+/-2 days of gestation. Asphyxia was induced by umbilical cord clamping and then delaying the onset of ventilation until mean carotid arterial pressures (CAPs) had decreased

AB - OBJECTIVE: At birth, an initial sustained inflation (SI) uniformly aerates the lungs, increases arterial oxygenation and rapidly improves circulatory recovery in asphyxiated newborns. We hypothesised that lung aeration, in the absence of an increase in arterial oxygenation, can increase heart rate (HR) in asphyxiated near-term lambs. INTERVENTIONS: Lambs were delivered and instrumented at 139+/-2 days of gestation. Asphyxia was induced by umbilical cord clamping and then delaying the onset of ventilation until mean carotid arterial pressures (CAPs) had decreased

UR - http://fn.bmj.com/content/100/4/F337.full.pdf

U2 - 10.1136/archdischild-2014-307319

DO - 10.1136/archdischild-2014-307319

M3 - Article

SN - 1359-2998

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JO - Archives of Disease in Childhood: Fetal and Neonatal Edition

JF - Archives of Disease in Childhood: Fetal and Neonatal Edition

IS - 4

ER -

The effect of oxygen content during an initial sustained inflation on heart rate in asphyxiated near-term lambs

Abstract

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NHMRC Research Fellowship

Unlocking the complexities of postnatal brain injury in preterm neonates.

Novel strategies for improving respiratory support and outcomes for preterm babies: ID 384100

Cite this

The effect of oxygen content during an initial sustained inflation on heart rate in asphyxiated near-term lambs

Abstract

Access to Document

Other files and links

Projects

NHMRC Research Fellowship

Unlocking the complexities of postnatal brain injury in preterm neonates.

Novel strategies for improving respiratory support and outcomes for preterm babies: ID 384100

Cite this