The effect of oxygen content during an initial sustained inflation on heart rate in asphyxiated near-term lambs

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Abstract

OBJECTIVE: At birth, an initial sustained inflation (SI) uniformly aerates the lungs, increases arterial oxygenation and rapidly improves circulatory recovery in asphyxiated newborns. We hypothesised that lung aeration, in the absence of an increase in arterial oxygenation, can increase heart rate (HR) in asphyxiated near-term lambs. INTERVENTIONS: Lambs were delivered and instrumented at 139+/-2 days of gestation. Asphyxia was induced by umbilical cord clamping and then delaying the onset of ventilation until mean carotid arterial pressures (CAPs) had decreased
Original languageEnglish
Pages (from-to)337 - 343
Number of pages7
JournalArchives of Disease in Childhood: Fetal and Neonatal Edition
Volume100
Issue number4
DOIs
Publication statusPublished - 2015

Cite this

@article{518ee154874746faab55bf7014330366,
title = "The effect of oxygen content during an initial sustained inflation on heart rate in asphyxiated near-term lambs",
abstract = "OBJECTIVE: At birth, an initial sustained inflation (SI) uniformly aerates the lungs, increases arterial oxygenation and rapidly improves circulatory recovery in asphyxiated newborns. We hypothesised that lung aeration, in the absence of an increase in arterial oxygenation, can increase heart rate (HR) in asphyxiated near-term lambs. INTERVENTIONS: Lambs were delivered and instrumented at 139+/-2 days of gestation. Asphyxia was induced by umbilical cord clamping and then delaying the onset of ventilation until mean carotid arterial pressures (CAPs) had decreased",
author = "Kristina Sobotka and Tracey Ong and Graeme Polglase and Crossley, {Kelly Jane} and Moss, {Timothy James Murugesan} and Hooper, {Stuart Brian}",
year = "2015",
doi = "10.1136/archdischild-2014-307319",
language = "English",
volume = "100",
pages = "337 -- 343",
journal = "Archives of Disease in Childhood: Fetal and Neonatal Edition",
issn = "1359-2998",
publisher = "BMJ Group",
number = "4",

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TY - JOUR

T1 - The effect of oxygen content during an initial sustained inflation on heart rate in asphyxiated near-term lambs

AU - Sobotka, Kristina

AU - Ong, Tracey

AU - Polglase, Graeme

AU - Crossley, Kelly Jane

AU - Moss, Timothy James Murugesan

AU - Hooper, Stuart Brian

PY - 2015

Y1 - 2015

N2 - OBJECTIVE: At birth, an initial sustained inflation (SI) uniformly aerates the lungs, increases arterial oxygenation and rapidly improves circulatory recovery in asphyxiated newborns. We hypothesised that lung aeration, in the absence of an increase in arterial oxygenation, can increase heart rate (HR) in asphyxiated near-term lambs. INTERVENTIONS: Lambs were delivered and instrumented at 139+/-2 days of gestation. Asphyxia was induced by umbilical cord clamping and then delaying the onset of ventilation until mean carotid arterial pressures (CAPs) had decreased

AB - OBJECTIVE: At birth, an initial sustained inflation (SI) uniformly aerates the lungs, increases arterial oxygenation and rapidly improves circulatory recovery in asphyxiated newborns. We hypothesised that lung aeration, in the absence of an increase in arterial oxygenation, can increase heart rate (HR) in asphyxiated near-term lambs. INTERVENTIONS: Lambs were delivered and instrumented at 139+/-2 days of gestation. Asphyxia was induced by umbilical cord clamping and then delaying the onset of ventilation until mean carotid arterial pressures (CAPs) had decreased

UR - http://fn.bmj.com/content/100/4/F337.full.pdf

U2 - 10.1136/archdischild-2014-307319

DO - 10.1136/archdischild-2014-307319

M3 - Article

VL - 100

SP - 337

EP - 343

JO - Archives of Disease in Childhood: Fetal and Neonatal Edition

JF - Archives of Disease in Childhood: Fetal and Neonatal Edition

SN - 1359-2998

IS - 4

ER -