The effect of immunosuppression on vascularised allografts. A preliminary report

K. Doi, G. DeSantis, D. I. Singer, J. V. Hurley, B. McC O'Brien, S. M. McKay, M. J. Hickey, B. F. Murphy

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Abstract

Five vascularized allografts of the knee joint were performed in dogs immunosuppressed with cyclosporin A and azathioprine. Three survived with normal function for 3 to 4 months after operation. One of the unsuccessful graft had a failed vascular anastomosis, the other an inadequate blood level of cyclosporin A. All three successful grafts healed well. In two, bone scans, radiographs and biopsies were indistinguishable from successful autografts; in the third the blood supply to the graft failed despite patent anastomoses but the graft healed well with good function. All three grafts were rejected within 2 to 3 weeks of withdrawal of cyclosporin A and azathioprine. In non-immunosuppressed dogs, allografts of the knee, both vascularised and non-vascularised, were rejected within a few days of operation. In two non-vascularised allografts, administration of cyclosporin and azathioprine had no apparent effect on the rate of rejection of the graft.

Original languageEnglish
Pages (from-to)576-582
Number of pages7
JournalThe Journal of Bone and Joint Surgery, British Volume
Volume71B
Issue number4
Publication statusPublished - 1 Jan 1989
Externally publishedYes

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