The effect of hypoxia on the functional and structural development of the chick brain

Candice Lauren Rodricks, Marie Elizabeth Gibbs, Margie Castillo-Melendez, Suzanne Lee Miller

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)


Decreased oxygen availability during gestation is linked with altered structural development of the brain and cognitive deficits after birth. Prehatch hypoxia can induce gross neuropathology such as brain lesions or more subtle injury including selective neuronal cell loss, white matter injury and gliosis. In the current study we used the developing chick embryo to determine whether 24h of hypoxia at different prehatch ages, embryonic day 10, 12 or 14 (E10, E12 or E14), resulted in an alteration in neuronal cell number or astrocyte density in brain areas associated with learning and memory. Twenty-four hours of hypoxia (14 oxygen) commencing at E10 resulted in an increase in the density of GFAP-positive astrocytes in the medial striatum (MSt) (P
Original languageEnglish
Pages (from-to)343 - 350
Number of pages8
JournalInternational Journal of Developmental Neuroscience
Issue number4
Publication statusPublished - 2010

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