The effect of hypophysectomy on inhibin production by adult rat ovaries: Changes in ovarian inhibin gene expression and serum inhibin

S. R. Davis; R. S. Carson; Z. Krozowski; H. G. Burger

doi:10.3109/09513599809029347

The effect of hypophysectomy on inhibin production by adult rat ovaries: Changes in ovarian inhibin gene expression and serum inhibin

S. R. Davis
, R. S. Carson
, Z. Krozowski
, H. G. Burger

Research output: Contribution to journal › Article › Research › peer-review

6 Citations (Scopus)

Abstract

We have investigated the effect of hypophysectomy on adult rat ovarian inhibin α and β_A-subunit mRNA, serum inhibin, and circulating gonadotropin levels. Immediate declines in ovarian inhibin gene expression and serum inhibin were observed following hypophysectomy, with a nadir on day 4. However, inhibin synthesis determined by these parameters was still apparent at 16 days post-hypophysectomy. Gonadotropin levels were suppressed following hypophysectomy and the fall in inhibin production was highly correlated with disappearance of FSH from the circulation. This study demonstrates that removal of pituitary gonadotropin stimulation results in diminished ovarian inhibin synthesis and provides further evidence indicating that FSH stimulates granulosa cell inhibin synthesis by enhancing inhibin gene transcription.

Original language	English
Pages (from-to)	223-232
Number of pages	10
Journal	Gynecological Endocrinology
Volume	2
Issue number	3
DOIs	https://doi.org/10.3109/09513599809029347
Publication status	Published - 1988

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title = "The effect of hypophysectomy on inhibin production by adult rat ovaries: Changes in ovarian inhibin gene expression and serum inhibin",

abstract = "We have investigated the effect of hypophysectomy on adult rat ovarian inhibin α and βA-subunit mRNA, serum inhibin, and circulating gonadotropin levels. Immediate declines in ovarian inhibin gene expression and serum inhibin were observed following hypophysectomy, with a nadir on day 4. However, inhibin synthesis determined by these parameters was still apparent at 16 days post-hypophysectomy. Gonadotropin levels were suppressed following hypophysectomy and the fall in inhibin production was highly correlated with disappearance of FSH from the circulation. This study demonstrates that removal of pituitary gonadotropin stimulation results in diminished ovarian inhibin synthesis and provides further evidence indicating that FSH stimulates granulosa cell inhibin synthesis by enhancing inhibin gene transcription.",

author = "Davis, \{S. R.\} and Carson, \{R. S.\} and Z. Krozowski and Burger, \{H. G.\}",

year = "1988",

doi = "10.3109/09513599809029347",

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journal = "Gynecological Endocrinology",

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T1 - The effect of hypophysectomy on inhibin production by adult rat ovaries

T2 - Changes in ovarian inhibin gene expression and serum inhibin

AU - Davis, S. R.

AU - Carson, R. S.

AU - Krozowski, Z.

AU - Burger, H. G.

PY - 1988

Y1 - 1988

N2 - We have investigated the effect of hypophysectomy on adult rat ovarian inhibin α and βA-subunit mRNA, serum inhibin, and circulating gonadotropin levels. Immediate declines in ovarian inhibin gene expression and serum inhibin were observed following hypophysectomy, with a nadir on day 4. However, inhibin synthesis determined by these parameters was still apparent at 16 days post-hypophysectomy. Gonadotropin levels were suppressed following hypophysectomy and the fall in inhibin production was highly correlated with disappearance of FSH from the circulation. This study demonstrates that removal of pituitary gonadotropin stimulation results in diminished ovarian inhibin synthesis and provides further evidence indicating that FSH stimulates granulosa cell inhibin synthesis by enhancing inhibin gene transcription.

AB - We have investigated the effect of hypophysectomy on adult rat ovarian inhibin α and βA-subunit mRNA, serum inhibin, and circulating gonadotropin levels. Immediate declines in ovarian inhibin gene expression and serum inhibin were observed following hypophysectomy, with a nadir on day 4. However, inhibin synthesis determined by these parameters was still apparent at 16 days post-hypophysectomy. Gonadotropin levels were suppressed following hypophysectomy and the fall in inhibin production was highly correlated with disappearance of FSH from the circulation. This study demonstrates that removal of pituitary gonadotropin stimulation results in diminished ovarian inhibin synthesis and provides further evidence indicating that FSH stimulates granulosa cell inhibin synthesis by enhancing inhibin gene transcription.

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M3 - Article

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AN - SCOPUS:0024083664

SN - 0951-3590

VL - 2

SP - 223

EP - 232

JO - Gynecological Endocrinology

JF - Gynecological Endocrinology

IS - 3

ER -

The effect of hypophysectomy on inhibin production by adult rat ovaries: Changes in ovarian inhibin gene expression and serum inhibin

Abstract

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