Projects per year
Abstract
The binding of melittin to a range of phospholipid bilayers was studied using dual polarisation interferometry and atomic force microscopy. The phospholipid model membranes included zwitterionic dimyristylphosphatidylcholine (DMPC), together with mixtures of DMPC/dimyristylphosphatidylglycerol (DMPG) and DMPC/DMPG/cholesterol. Melittin caused significant disruption on all bilayers, but differences in morphological changes during binding were different on each membrane. Overall, the results demonstrate that the process of membrane disruption follows distinct structural changes for different lipid mixtures irrespective of the strength of binding to the membrane surface.
Original language | English |
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Pages (from-to) | 195-201 |
Number of pages | 7 |
Journal | Australian Journal of Chemistry |
Volume | 73 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2020 |
Projects
- 2 Finished
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Selective targeting of microbes by peptides of the innate immune system
Aguilar, M. (Primary Chief Investigator (PCI)), Mark, A. (Partner Investigator (PI)) & Separovic, F. (Partner Investigator (PI))
NHMRC - National Health and Medical Research Council (Australia)
1/01/13 → 31/12/15
Project: Research
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The Mechanism of Membrane Disruption by Antimicrobial Peptides
Aguilar, M. (Primary Chief Investigator (PCI)), Mark, A. (Chief Investigator (CI)) & Separovic, F. (Chief Investigator (CI))
ARC - Australian Research Council, University of Melbourne
4/01/11 → 31/12/13
Project: Research