Abstract
Objective: The objective of this study was to evaluate the current evidence regarding the effect of antiepileptic drugs (AEDs)on epileptiform discharge (ED)burden in genetic generalized epilepsy (GGE). Methods: We conducted a comprehensive literature search of PubMed, Embase, PsycINFO, and the Web of Science Core Collection databases using the keywords ‘genetic generalized epilepsy’, ‘antiepileptic drugs’ and ‘epileptiform discharge’. Primary human studies published in English that reported the effect of AEDs on EDs captured on electroencephalogram (EEG)recordings of at least 24 h in duration in patients with GGE were included. Results: Six studies published between 1984 and 2017, which reported the effect of AEDs on EDs, involving a total of 116 patients with GGE, were analyzed. Our systematic review found a tendency for AEDs to reduce ED density, frequency, cumulative duration, and burst duration in GGE. Furthermore, we found evidence that the AED-mediated reduction in ED burden was associated with improved seizure control and cognitive outcomes. Conclusions: Antiepileptic drugs tend to reduce ED burden in GGE, but the significance of this association remains uncertain.
| Original language | English |
|---|---|
| Pages (from-to) | 175-182 |
| Number of pages | 8 |
| Journal | Epilepsy & Behavior |
| Volume | 96 |
| DOIs | |
| Publication status | Published - 1 Jul 2019 |
Keywords
- Antiepileptic drugs
- Cognition
- EEG
- Generalized epilepsy
- Seizure control
- Treatment response
Cite this
}
The effect of antiepileptic drugs on epileptiform discharges in genetic generalized epilepsy : A systematic review. / Gunawan, Claire; Seneviratne, Udaya; D'Souza, Wendyl.
In: Epilepsy & Behavior, Vol. 96, 01.07.2019, p. 175-182.Research output: Contribution to journal › Review Article › Research › peer-review
TY - JOUR
T1 - The effect of antiepileptic drugs on epileptiform discharges in genetic generalized epilepsy
T2 - A systematic review
AU - Gunawan, Claire
AU - Seneviratne, Udaya
AU - D'Souza, Wendyl
PY - 2019/7/1
Y1 - 2019/7/1
N2 - Objective: The objective of this study was to evaluate the current evidence regarding the effect of antiepileptic drugs (AEDs)on epileptiform discharge (ED)burden in genetic generalized epilepsy (GGE). Methods: We conducted a comprehensive literature search of PubMed, Embase, PsycINFO, and the Web of Science Core Collection databases using the keywords ‘genetic generalized epilepsy’, ‘antiepileptic drugs’ and ‘epileptiform discharge’. Primary human studies published in English that reported the effect of AEDs on EDs captured on electroencephalogram (EEG)recordings of at least 24 h in duration in patients with GGE were included. Results: Six studies published between 1984 and 2017, which reported the effect of AEDs on EDs, involving a total of 116 patients with GGE, were analyzed. Our systematic review found a tendency for AEDs to reduce ED density, frequency, cumulative duration, and burst duration in GGE. Furthermore, we found evidence that the AED-mediated reduction in ED burden was associated with improved seizure control and cognitive outcomes. Conclusions: Antiepileptic drugs tend to reduce ED burden in GGE, but the significance of this association remains uncertain.
AB - Objective: The objective of this study was to evaluate the current evidence regarding the effect of antiepileptic drugs (AEDs)on epileptiform discharge (ED)burden in genetic generalized epilepsy (GGE). Methods: We conducted a comprehensive literature search of PubMed, Embase, PsycINFO, and the Web of Science Core Collection databases using the keywords ‘genetic generalized epilepsy’, ‘antiepileptic drugs’ and ‘epileptiform discharge’. Primary human studies published in English that reported the effect of AEDs on EDs captured on electroencephalogram (EEG)recordings of at least 24 h in duration in patients with GGE were included. Results: Six studies published between 1984 and 2017, which reported the effect of AEDs on EDs, involving a total of 116 patients with GGE, were analyzed. Our systematic review found a tendency for AEDs to reduce ED density, frequency, cumulative duration, and burst duration in GGE. Furthermore, we found evidence that the AED-mediated reduction in ED burden was associated with improved seizure control and cognitive outcomes. Conclusions: Antiepileptic drugs tend to reduce ED burden in GGE, but the significance of this association remains uncertain.
KW - Antiepileptic drugs
KW - Cognition
KW - EEG
KW - Generalized epilepsy
KW - Seizure control
KW - Treatment response
UR - http://www.scopus.com/inward/record.url?scp=85066093845&partnerID=8YFLogxK
U2 - 10.1016/j.yebeh.2019.04.030
DO - 10.1016/j.yebeh.2019.04.030
M3 - Review Article
VL - 96
SP - 175
EP - 182
JO - Epilepsy & Behavior
JF - Epilepsy & Behavior
SN - 1525-5050
ER -