The effect of 90 day administration of a high dose vitamin B-complex on work stress

Con Stough, Andrew Scholey, Jenny Lloyd, Jo Spong, Stephen Myers, Luke A. Downey

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)


Objective Occupational stress is increasing in Western societies and the impact is significant at a personal, organisational and community level. The present study examined for the first time the efficacy of 3â months administration of two forms of high dose vitamin B complex on mood and psychological strain associated with chronic work stress. Method Sixty participants completed the 3-month, double-blind, randomised, placebo-controlled trial in which personality, work demands, mood, anxiety and strain were assessed. Results After individual differences in personality and work demands were statistically controlled, the vitamin B complex treatment groups reported significantly lower personal strain and a reduction in confusion and depressed/dejected mood after 12 weeks. There were no treatment-related changes in other measures of mood and anxiety. Discussion The results of the study are consistent with two previous studies examining multivitamin supplementation and personal (non-work) feelings of strain and suggestive of significant decreases in the experience of workplace stress after 90 day supplementation of a B multivitamin. Conclusion Given the direct and indirect costs of workplace stress, these findings point to the utility of a cost-effective treatment for the mood and psychological strain effects of occupational stress. These findings may have important personal health, organisational and societal outcomes given the rising cost and incidence of workplace stress.

Original languageEnglish
Pages (from-to)470-476
Number of pages7
JournalHuman Psychopharmacology
Issue number7
Publication statusPublished - Oct 2011
Externally publishedYes


  • mood
  • occupational stress
  • RCT
  • stress
  • vitamin B

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