TY - JOUR
T1 - The Dual Role of Conjugated Linoleic Acid in Obesity and Metabolic Disorders
AU - Rajendran, Magendran
AU - Palani, Shanmugasundaram
AU - Singh, Thakur Gurjeet
AU - Oliver, Brian
AU - Dua, Kaml
AU - Subramaniyan, Vetriselvan
AU - Narayanan, Kumaran
N1 - Publisher Copyright:
© 2025 The Author(s). Food Science & Nutrition published by Wiley Periodicals LLC.
PY - 2025/7
Y1 - 2025/7
N2 - Conjugated Linoleic Acid (cis-9, trans-11, CLA)/(trans-10, cis-12, CLA) has been extensively studied for its role in obesity control and metabolic diseases. This review explores the molecular characteristics of CLA, its metabolic pathways, and its inconsistent effects on lipid metabolism, adipogenesis, energy expenditure, and inflammation. Preclinical and clinical studies suggest that CLA may promote fat oxidation and modulate adipocyte function; however, inconsistent findings highlight dose-dependent outcomes and individual variability in response. The dual nature of CLA, showing both beneficial and adverse effects, raises questions about its long-term safety and efficacy. This review critically examines CLA's molecular role in obesity and metabolic regulation, providing insights into its therapeutic promise and limitations. Future research should focus on personalized approaches to CLA supplementation, considering genetic and lifestyle factors for tailored nutritional guidance.
AB - Conjugated Linoleic Acid (cis-9, trans-11, CLA)/(trans-10, cis-12, CLA) has been extensively studied for its role in obesity control and metabolic diseases. This review explores the molecular characteristics of CLA, its metabolic pathways, and its inconsistent effects on lipid metabolism, adipogenesis, energy expenditure, and inflammation. Preclinical and clinical studies suggest that CLA may promote fat oxidation and modulate adipocyte function; however, inconsistent findings highlight dose-dependent outcomes and individual variability in response. The dual nature of CLA, showing both beneficial and adverse effects, raises questions about its long-term safety and efficacy. This review critically examines CLA's molecular role in obesity and metabolic regulation, providing insights into its therapeutic promise and limitations. Future research should focus on personalized approaches to CLA supplementation, considering genetic and lifestyle factors for tailored nutritional guidance.
KW - conjugated linoleic acid (cis-9, trans-11, CLA)/(trans-10, cis-12, CLA)
KW - insulin sensitivity
KW - lipid metabolism
KW - metabolic disorders
KW - obesity
UR - https://www.scopus.com/pages/publications/105011184294
U2 - 10.1002/fsn3.70582
DO - 10.1002/fsn3.70582
M3 - Review Article
C2 - 40697709
AN - SCOPUS:105011184294
SN - 2048-7177
VL - 13
JO - Food Science and Nutrition
JF - Food Science and Nutrition
IS - 7
M1 - e70582
ER -
