The Diverse Family of MR1-Restricted T Cells

Nicholas A Gherardin; James McCluskey; Jamie Rossjohn; Dale I. Godfrey

doi:10.4049/jimmunol.1801091

The Diverse Family of MR1-Restricted T Cells

Nicholas A Gherardin
, James McCluskey
, Jamie Rossjohn
, Dale I. Godfrey

Research output: Contribution to journal › Review Article › Research › peer-review

38 Citations (Scopus)

Abstract

Mucosal-associated invariant T (MAIT) cells are characterized by a semi-invariant TCR that recognizes Vitamin B metabolite Ags presented by the MHC-related molecule MR1. Their Ag restriction determines a unique developmental lineage, imbuing a tissue-homing, preprimed phenotype with antimicrobial function. A growing body of literature indicates that MR1-restricted T cells are more diverse than the MAIT term implies. Namely, it is increasingly clear that TCR a- And TCR b-chain diversity within the MR1-restricted repertoire provides a potential mechanism of Ag discrimination, and context-dependent functional variation suggests a role for MR1-restricted T cells in diverse physiological settings. In this paper, we summarize MR1-restricted T cell biology, with an emphasis on TCR diversity, Ag discrimination, and functional heterogeneity. The Journal of Immunology.

Original language	English
Pages (from-to)	2862-2871
Number of pages	10
Journal	Journal of Immunology
Volume	201
Issue number	10
DOIs	https://doi.org/10.4049/jimmunol.1801091
Publication status	Published - 15 Nov 2018

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10.4049/jimmunol.1801091

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title = "The Diverse Family of MR1-Restricted T Cells",

abstract = "Mucosal-associated invariant T (MAIT) cells are characterized by a semi-invariant TCR that recognizes Vitamin B metabolite Ags presented by the MHC-related molecule MR1. Their Ag restriction determines a unique developmental lineage, imbuing a tissue-homing, preprimed phenotype with antimicrobial function. A growing body of literature indicates that MR1-restricted T cells are more diverse than the MAIT term implies. Namely, it is increasingly clear that TCR a- And TCR b-chain diversity within the MR1-restricted repertoire provides a potential mechanism of Ag discrimination, and context-dependent functional variation suggests a role for MR1-restricted T cells in diverse physiological settings. In this paper, we summarize MR1-restricted T cell biology, with an emphasis on TCR diversity, Ag discrimination, and functional heterogeneity. The Journal of Immunology.",

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year = "2018",

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doi = "10.4049/jimmunol.1801091",

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AU - Gherardin, Nicholas A

AU - McCluskey, James

AU - Rossjohn, Jamie

AU - Godfrey, Dale I.

PY - 2018/11/15

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N2 - Mucosal-associated invariant T (MAIT) cells are characterized by a semi-invariant TCR that recognizes Vitamin B metabolite Ags presented by the MHC-related molecule MR1. Their Ag restriction determines a unique developmental lineage, imbuing a tissue-homing, preprimed phenotype with antimicrobial function. A growing body of literature indicates that MR1-restricted T cells are more diverse than the MAIT term implies. Namely, it is increasingly clear that TCR a- And TCR b-chain diversity within the MR1-restricted repertoire provides a potential mechanism of Ag discrimination, and context-dependent functional variation suggests a role for MR1-restricted T cells in diverse physiological settings. In this paper, we summarize MR1-restricted T cell biology, with an emphasis on TCR diversity, Ag discrimination, and functional heterogeneity. The Journal of Immunology.

AB - Mucosal-associated invariant T (MAIT) cells are characterized by a semi-invariant TCR that recognizes Vitamin B metabolite Ags presented by the MHC-related molecule MR1. Their Ag restriction determines a unique developmental lineage, imbuing a tissue-homing, preprimed phenotype with antimicrobial function. A growing body of literature indicates that MR1-restricted T cells are more diverse than the MAIT term implies. Namely, it is increasingly clear that TCR a- And TCR b-chain diversity within the MR1-restricted repertoire provides a potential mechanism of Ag discrimination, and context-dependent functional variation suggests a role for MR1-restricted T cells in diverse physiological settings. In this paper, we summarize MR1-restricted T cell biology, with an emphasis on TCR diversity, Ag discrimination, and functional heterogeneity. The Journal of Immunology.

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The Diverse Family of MR1-Restricted T Cells

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ARC Centre of Excellence in Advanced Molecular Imaging

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The Diverse Family of MR1-Restricted T Cells

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ARC Centre of Excellence in Advanced Molecular Imaging

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