The Diverse Family of MR1-Restricted T Cells

Nicholas A Gherardin, James McCluskey, Jamie Rossjohn, Dale I. Godfrey

Research output: Contribution to journalReview ArticleResearchpeer-review

8 Citations (Scopus)

Abstract

Mucosal-associated invariant T (MAIT) cells are characterized by a semi-invariant TCR that recognizes Vitamin B metabolite Ags presented by the MHC-related molecule MR1. Their Ag restriction determines a unique developmental lineage, imbuing a tissue-homing, preprimed phenotype with antimicrobial function. A growing body of literature indicates that MR1-restricted T cells are more diverse than the MAIT term implies. Namely, it is increasingly clear that TCR a- And TCR b-chain diversity within the MR1-restricted repertoire provides a potential mechanism of Ag discrimination, and context-dependent functional variation suggests a role for MR1-restricted T cells in diverse physiological settings. In this paper, we summarize MR1-restricted T cell biology, with an emphasis on TCR diversity, Ag discrimination, and functional heterogeneity. The Journal of Immunology.

Original languageEnglish
Pages (from-to)2862-2871
Number of pages10
JournalJournal of Immunology
Volume201
Issue number10
DOIs
Publication statusPublished - 15 Nov 2018

Cite this

Gherardin, N. A., McCluskey, J., Rossjohn, J., & Godfrey, D. I. (2018). The Diverse Family of MR1-Restricted T Cells. Journal of Immunology, 201(10), 2862-2871. https://doi.org/10.4049/jimmunol.1801091
Gherardin, Nicholas A ; McCluskey, James ; Rossjohn, Jamie ; Godfrey, Dale I. / The Diverse Family of MR1-Restricted T Cells. In: Journal of Immunology. 2018 ; Vol. 201, No. 10. pp. 2862-2871.
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Gherardin, NA, McCluskey, J, Rossjohn, J & Godfrey, DI 2018, 'The Diverse Family of MR1-Restricted T Cells', Journal of Immunology, vol. 201, no. 10, pp. 2862-2871. https://doi.org/10.4049/jimmunol.1801091

The Diverse Family of MR1-Restricted T Cells. / Gherardin, Nicholas A; McCluskey, James; Rossjohn, Jamie; Godfrey, Dale I.

In: Journal of Immunology, Vol. 201, No. 10, 15.11.2018, p. 2862-2871.

Research output: Contribution to journalReview ArticleResearchpeer-review

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