Abstract
Mucosal-associated invariant T (MAIT) cells are characterized by a semi-invariant TCR that recognizes Vitamin B metabolite Ags presented by the MHC-related molecule MR1. Their Ag restriction determines a unique developmental lineage, imbuing a tissue-homing, preprimed phenotype with antimicrobial function. A growing body of literature indicates that MR1-restricted T cells are more diverse than the MAIT term implies. Namely, it is increasingly clear that TCR a- And TCR b-chain diversity within the MR1-restricted repertoire provides a potential mechanism of Ag discrimination, and context-dependent functional variation suggests a role for MR1-restricted T cells in diverse physiological settings. In this paper, we summarize MR1-restricted T cell biology, with an emphasis on TCR diversity, Ag discrimination, and functional heterogeneity. The Journal of Immunology.
| Original language | English |
|---|---|
| Pages (from-to) | 2862-2871 |
| Number of pages | 10 |
| Journal | Journal of Immunology |
| Volume | 201 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 15 Nov 2018 |
Cite this
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The Diverse Family of MR1-Restricted T Cells. / Gherardin, Nicholas A; McCluskey, James; Rossjohn, Jamie; Godfrey, Dale I.
In: Journal of Immunology, Vol. 201, No. 10, 15.11.2018, p. 2862-2871.Research output: Contribution to journal › Review Article › Research › peer-review
TY - JOUR
T1 - The Diverse Family of MR1-Restricted T Cells
AU - Gherardin, Nicholas A
AU - McCluskey, James
AU - Rossjohn, Jamie
AU - Godfrey, Dale I.
PY - 2018/11/15
Y1 - 2018/11/15
N2 - Mucosal-associated invariant T (MAIT) cells are characterized by a semi-invariant TCR that recognizes Vitamin B metabolite Ags presented by the MHC-related molecule MR1. Their Ag restriction determines a unique developmental lineage, imbuing a tissue-homing, preprimed phenotype with antimicrobial function. A growing body of literature indicates that MR1-restricted T cells are more diverse than the MAIT term implies. Namely, it is increasingly clear that TCR a- And TCR b-chain diversity within the MR1-restricted repertoire provides a potential mechanism of Ag discrimination, and context-dependent functional variation suggests a role for MR1-restricted T cells in diverse physiological settings. In this paper, we summarize MR1-restricted T cell biology, with an emphasis on TCR diversity, Ag discrimination, and functional heterogeneity. The Journal of Immunology.
AB - Mucosal-associated invariant T (MAIT) cells are characterized by a semi-invariant TCR that recognizes Vitamin B metabolite Ags presented by the MHC-related molecule MR1. Their Ag restriction determines a unique developmental lineage, imbuing a tissue-homing, preprimed phenotype with antimicrobial function. A growing body of literature indicates that MR1-restricted T cells are more diverse than the MAIT term implies. Namely, it is increasingly clear that TCR a- And TCR b-chain diversity within the MR1-restricted repertoire provides a potential mechanism of Ag discrimination, and context-dependent functional variation suggests a role for MR1-restricted T cells in diverse physiological settings. In this paper, we summarize MR1-restricted T cell biology, with an emphasis on TCR diversity, Ag discrimination, and functional heterogeneity. The Journal of Immunology.
UR - http://www.scopus.com/inward/record.url?scp=85056284513&partnerID=8YFLogxK
U2 - 10.4049/jimmunol.1801091
DO - 10.4049/jimmunol.1801091
M3 - Review Article
C2 - 30397170
AN - SCOPUS:85056284513
VL - 201
SP - 2862
EP - 2871
JO - Journal of Immunology
JF - Journal of Immunology
SN - 0022-1767
IS - 10
ER -