'The difference in determinants of Chlamydia trachomatis and Mycoplasma genitalium in a sample of young Australian women'

Jennifer Walker, Christopher K. Fairley, Catriona S. Bradshaw, Sepehr N. Tabrizi, Marcus Y. Chen, Jimmy Twin, Basil Donovan, John K. Kaldor, Kathleen McNamee, Eve Urban, Sandra Walker, Marian Currie, Hudson Birden, Francis Bowden, Jane Gunn, Marie Pirotta, Lyle Gurrin, Veerakathy Harindra, Suzanne Garland, Jane S. Hocking

Research output: Contribution to journalArticleResearchpeer-review

54 Citations (Scopus)

Abstract

Background: Differences in the determinants of Chlamydia trachomatis ('chlamydia') and Mycoplasma genitalium (MG) genital infection in women are not well understood.Methods: A cohort study of 16 to 25 year old Australian women recruited from primary health care clinics, aimed to determine chlamydia and MG prevalence and incidence. Vaginal swabs collected at recruitment were used to measure chlamydia and MG prevalence, organism-load and chlamydia-serovar a cross-sectional analysis undertaken on the baseline results is presented here.Results: Of 1116 participants, chlamydia prevalence was 4.9% (95% CI: 2.9, 7.0) (n = 55) and MG prevalence was 2.4% (95% CI: 1.5, 3.3) (n = 27). Differences in the determinants were found - chlamydia not MG, was associated with younger age [AOR:0.9 (95% CI: 0.8, 1.0)] and recent antibiotic use [AOR:0.4 (95% CI: 0.2, 1.0)], and MG not chlamydia was associated with symptoms [AOR:2.1 (95% CI: 1.1, 4.0)]. Having two or more partners in last 12 months was more strongly associated with chlamydia [AOR:6.4 (95% CI: 3.6, 11.3)] than MG [AOR:2.2 (95% CI: 1.0, 4.6)] but unprotected sex with three or more partners was less strongly associated with chlamydia [AOR:3.1 (95%CI: 1.0, 9.5)] than MG [AOR:16.6 (95%CI: 2.0, 138.0)]. Median organism load for MG was 100 times lower (5.7 × 104/swab) than chlamydia (5.6 × 106/swab) (p < 0.01) and not associated with age or symptoms for chlamydia or MG.Conclusions: These results demonstrate significant chlamydia and MG prevalence in Australian women, and suggest that the differences in strengths of association between numbers of sexual partners and unprotected sex and chlamydia and MG might be due to differences in the transmission dynamics between these infections.

Original languageEnglish
Article number35
JournalBMC Infectious Diseases
Volume11
DOIs
Publication statusPublished - 1 Feb 2011

Cite this

Walker, Jennifer ; Fairley, Christopher K. ; Bradshaw, Catriona S. ; Tabrizi, Sepehr N. ; Chen, Marcus Y. ; Twin, Jimmy ; Donovan, Basil ; Kaldor, John K. ; McNamee, Kathleen ; Urban, Eve ; Walker, Sandra ; Currie, Marian ; Birden, Hudson ; Bowden, Francis ; Gunn, Jane ; Pirotta, Marie ; Gurrin, Lyle ; Harindra, Veerakathy ; Garland, Suzanne ; Hocking, Jane S. / 'The difference in determinants of Chlamydia trachomatis and Mycoplasma genitalium in a sample of young Australian women'. In: BMC Infectious Diseases. 2011 ; Vol. 11.
@article{3c4a3ea72027424196985b80dd0428c8,
title = "'The difference in determinants of Chlamydia trachomatis and Mycoplasma genitalium in a sample of young Australian women'",
abstract = "Background: Differences in the determinants of Chlamydia trachomatis ('chlamydia') and Mycoplasma genitalium (MG) genital infection in women are not well understood.Methods: A cohort study of 16 to 25 year old Australian women recruited from primary health care clinics, aimed to determine chlamydia and MG prevalence and incidence. Vaginal swabs collected at recruitment were used to measure chlamydia and MG prevalence, organism-load and chlamydia-serovar a cross-sectional analysis undertaken on the baseline results is presented here.Results: Of 1116 participants, chlamydia prevalence was 4.9{\%} (95{\%} CI: 2.9, 7.0) (n = 55) and MG prevalence was 2.4{\%} (95{\%} CI: 1.5, 3.3) (n = 27). Differences in the determinants were found - chlamydia not MG, was associated with younger age [AOR:0.9 (95{\%} CI: 0.8, 1.0)] and recent antibiotic use [AOR:0.4 (95{\%} CI: 0.2, 1.0)], and MG not chlamydia was associated with symptoms [AOR:2.1 (95{\%} CI: 1.1, 4.0)]. Having two or more partners in last 12 months was more strongly associated with chlamydia [AOR:6.4 (95{\%} CI: 3.6, 11.3)] than MG [AOR:2.2 (95{\%} CI: 1.0, 4.6)] but unprotected sex with three or more partners was less strongly associated with chlamydia [AOR:3.1 (95{\%}CI: 1.0, 9.5)] than MG [AOR:16.6 (95{\%}CI: 2.0, 138.0)]. Median organism load for MG was 100 times lower (5.7 × 104/swab) than chlamydia (5.6 × 106/swab) (p < 0.01) and not associated with age or symptoms for chlamydia or MG.Conclusions: These results demonstrate significant chlamydia and MG prevalence in Australian women, and suggest that the differences in strengths of association between numbers of sexual partners and unprotected sex and chlamydia and MG might be due to differences in the transmission dynamics between these infections.",
author = "Jennifer Walker and Fairley, {Christopher K.} and Bradshaw, {Catriona S.} and Tabrizi, {Sepehr N.} and Chen, {Marcus Y.} and Jimmy Twin and Basil Donovan and Kaldor, {John K.} and Kathleen McNamee and Eve Urban and Sandra Walker and Marian Currie and Hudson Birden and Francis Bowden and Jane Gunn and Marie Pirotta and Lyle Gurrin and Veerakathy Harindra and Suzanne Garland and Hocking, {Jane S.}",
year = "2011",
month = "2",
day = "1",
doi = "10.1186/1471-2334-11-35",
language = "English",
volume = "11",
journal = "BMC Infectious Diseases",
issn = "1471-2334",
publisher = "Springer-Verlag London Ltd.",

}

Walker, J, Fairley, CK, Bradshaw, CS, Tabrizi, SN, Chen, MY, Twin, J, Donovan, B, Kaldor, JK, McNamee, K, Urban, E, Walker, S, Currie, M, Birden, H, Bowden, F, Gunn, J, Pirotta, M, Gurrin, L, Harindra, V, Garland, S & Hocking, JS 2011, ''The difference in determinants of Chlamydia trachomatis and Mycoplasma genitalium in a sample of young Australian women'', BMC Infectious Diseases, vol. 11, 35. https://doi.org/10.1186/1471-2334-11-35

'The difference in determinants of Chlamydia trachomatis and Mycoplasma genitalium in a sample of young Australian women'. / Walker, Jennifer; Fairley, Christopher K.; Bradshaw, Catriona S.; Tabrizi, Sepehr N.; Chen, Marcus Y.; Twin, Jimmy; Donovan, Basil; Kaldor, John K.; McNamee, Kathleen; Urban, Eve; Walker, Sandra; Currie, Marian; Birden, Hudson; Bowden, Francis; Gunn, Jane; Pirotta, Marie; Gurrin, Lyle; Harindra, Veerakathy; Garland, Suzanne; Hocking, Jane S.

In: BMC Infectious Diseases, Vol. 11, 35, 01.02.2011.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - 'The difference in determinants of Chlamydia trachomatis and Mycoplasma genitalium in a sample of young Australian women'

AU - Walker, Jennifer

AU - Fairley, Christopher K.

AU - Bradshaw, Catriona S.

AU - Tabrizi, Sepehr N.

AU - Chen, Marcus Y.

AU - Twin, Jimmy

AU - Donovan, Basil

AU - Kaldor, John K.

AU - McNamee, Kathleen

AU - Urban, Eve

AU - Walker, Sandra

AU - Currie, Marian

AU - Birden, Hudson

AU - Bowden, Francis

AU - Gunn, Jane

AU - Pirotta, Marie

AU - Gurrin, Lyle

AU - Harindra, Veerakathy

AU - Garland, Suzanne

AU - Hocking, Jane S.

PY - 2011/2/1

Y1 - 2011/2/1

N2 - Background: Differences in the determinants of Chlamydia trachomatis ('chlamydia') and Mycoplasma genitalium (MG) genital infection in women are not well understood.Methods: A cohort study of 16 to 25 year old Australian women recruited from primary health care clinics, aimed to determine chlamydia and MG prevalence and incidence. Vaginal swabs collected at recruitment were used to measure chlamydia and MG prevalence, organism-load and chlamydia-serovar a cross-sectional analysis undertaken on the baseline results is presented here.Results: Of 1116 participants, chlamydia prevalence was 4.9% (95% CI: 2.9, 7.0) (n = 55) and MG prevalence was 2.4% (95% CI: 1.5, 3.3) (n = 27). Differences in the determinants were found - chlamydia not MG, was associated with younger age [AOR:0.9 (95% CI: 0.8, 1.0)] and recent antibiotic use [AOR:0.4 (95% CI: 0.2, 1.0)], and MG not chlamydia was associated with symptoms [AOR:2.1 (95% CI: 1.1, 4.0)]. Having two or more partners in last 12 months was more strongly associated with chlamydia [AOR:6.4 (95% CI: 3.6, 11.3)] than MG [AOR:2.2 (95% CI: 1.0, 4.6)] but unprotected sex with three or more partners was less strongly associated with chlamydia [AOR:3.1 (95%CI: 1.0, 9.5)] than MG [AOR:16.6 (95%CI: 2.0, 138.0)]. Median organism load for MG was 100 times lower (5.7 × 104/swab) than chlamydia (5.6 × 106/swab) (p < 0.01) and not associated with age or symptoms for chlamydia or MG.Conclusions: These results demonstrate significant chlamydia and MG prevalence in Australian women, and suggest that the differences in strengths of association between numbers of sexual partners and unprotected sex and chlamydia and MG might be due to differences in the transmission dynamics between these infections.

AB - Background: Differences in the determinants of Chlamydia trachomatis ('chlamydia') and Mycoplasma genitalium (MG) genital infection in women are not well understood.Methods: A cohort study of 16 to 25 year old Australian women recruited from primary health care clinics, aimed to determine chlamydia and MG prevalence and incidence. Vaginal swabs collected at recruitment were used to measure chlamydia and MG prevalence, organism-load and chlamydia-serovar a cross-sectional analysis undertaken on the baseline results is presented here.Results: Of 1116 participants, chlamydia prevalence was 4.9% (95% CI: 2.9, 7.0) (n = 55) and MG prevalence was 2.4% (95% CI: 1.5, 3.3) (n = 27). Differences in the determinants were found - chlamydia not MG, was associated with younger age [AOR:0.9 (95% CI: 0.8, 1.0)] and recent antibiotic use [AOR:0.4 (95% CI: 0.2, 1.0)], and MG not chlamydia was associated with symptoms [AOR:2.1 (95% CI: 1.1, 4.0)]. Having two or more partners in last 12 months was more strongly associated with chlamydia [AOR:6.4 (95% CI: 3.6, 11.3)] than MG [AOR:2.2 (95% CI: 1.0, 4.6)] but unprotected sex with three or more partners was less strongly associated with chlamydia [AOR:3.1 (95%CI: 1.0, 9.5)] than MG [AOR:16.6 (95%CI: 2.0, 138.0)]. Median organism load for MG was 100 times lower (5.7 × 104/swab) than chlamydia (5.6 × 106/swab) (p < 0.01) and not associated with age or symptoms for chlamydia or MG.Conclusions: These results demonstrate significant chlamydia and MG prevalence in Australian women, and suggest that the differences in strengths of association between numbers of sexual partners and unprotected sex and chlamydia and MG might be due to differences in the transmission dynamics between these infections.

UR - http://www.scopus.com/inward/record.url?scp=79351468976&partnerID=8YFLogxK

U2 - 10.1186/1471-2334-11-35

DO - 10.1186/1471-2334-11-35

M3 - Article

VL - 11

JO - BMC Infectious Diseases

JF - BMC Infectious Diseases

SN - 1471-2334

M1 - 35

ER -