TY - JOUR
T1 - The diagnostic and therapeutic challenges of Grade 3B follicular lymphoma
AU - Barraclough, Allison
AU - Bishton, Mark
AU - Cheah, Chan Y.
AU - Villa, Diego
AU - Hawkes, Eliza A.
PY - 2021/10
Y1 - 2021/10
N2 - Grade 3B follicular lymphoma (G3B FL) is rare, accounting for only 5–10% of FLs. Not only has it been routinely excluded from clinical trials, but data published on diagnosis, outcomes, choice of therapies and role of imaging are conflicting. With the advent of increasingly diverse treatment options for low-grade (G1–3A) FL, and the molecular subcategorisation of high-grade B-cell lymphomas, characterisation and treatment of G3B FL is ever more important as extrapolation of data becomes more difficult. New data have emerged exploring unique genetic characteristics, specific features on positron emission tomography imaging, choice of therapy, and outcomes of G3B FL in the current era. The present review will summarise and appraise these new data, and offer recommendations based on current evidence.
AB - Grade 3B follicular lymphoma (G3B FL) is rare, accounting for only 5–10% of FLs. Not only has it been routinely excluded from clinical trials, but data published on diagnosis, outcomes, choice of therapies and role of imaging are conflicting. With the advent of increasingly diverse treatment options for low-grade (G1–3A) FL, and the molecular subcategorisation of high-grade B-cell lymphomas, characterisation and treatment of G3B FL is ever more important as extrapolation of data becomes more difficult. New data have emerged exploring unique genetic characteristics, specific features on positron emission tomography imaging, choice of therapy, and outcomes of G3B FL in the current era. The present review will summarise and appraise these new data, and offer recommendations based on current evidence.
KW - lymphoid malignancies
KW - lymphoma
KW - lymphoproliferative disease
KW - non-Hodgkin lymphoma
UR - http://www.scopus.com/inward/record.url?scp=85102300384&partnerID=8YFLogxK
U2 - 10.1111/bjh.17404
DO - 10.1111/bjh.17404
M3 - Review Article
C2 - 33704790
AN - SCOPUS:85102300384
SN - 0007-1048
VL - 195
SP - 15
EP - 24
JO - British Journal of Haematology
JF - British Journal of Haematology
IS - 1
ER -