The developmental phases of zebrafish myogenesis

Samuel R. Keenan, Peter D. Currie

Research output: Contribution to journalReview ArticleResearchpeer-review

4 Citations (Scopus)

Abstract

The development and growth of vertebrate axial muscle have been studied for decades at both the descriptive and molecular level. The zebrafish has provided an attractive model system for investigating both muscle patterning and growth due to its simple axial musculature with spatially separated fibre types, which contrasts to complex muscle groups often deployed in amniotes. In recent years, new findings have reshaped previous concepts that define how final teleost muscle form is established and maintained. Here, we summarise recent findings in zebrafish embryonic myogenesis with a focus on fibre type specification, followed by an examination of the molecular mechanisms that control muscle growth with emphasis on the role of the dermomyotome-like external cell layer. We also consider these data sets in a comparative context to gain insight into the evolution of axial myogenic patterning systems within the vertebrate lineage.

Original languageEnglish
Article number12
Number of pages21
JournalJournal of Developmental Biology
Volume7
Issue number2
DOIs
Publication statusPublished - 2 Jun 2019

Keywords

  • Adaxial cells
  • Development
  • Evolution
  • External cell layer
  • Growth
  • Muscle
  • Primary myogenesis
  • Secondary myogenesis
  • Zebrafish

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