The Developmental Origins of Renal Dysfunction

James S.M. Cuffe, Sarah L. Walton, Karen M. Moritz

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Abstract

Impairments in renal function can contribute to multiple disorders including chronic kidney disease and hypertension. Although adult onset renal dysfunction may in part be attributable to lifestyle choices or other morbidities, such as diabetes, the "developmental origins of health and disease" hypothesis has suggested that impaired renal development may predispose offspring to later renal disease. This chapter will detail the epidemiological and experimental evidence highlighting the importance of impaired kidney development in the programming of adult renal dysfunction and associated diseases. Emphasis will be placed on links between a low nephron endowment and increased risk of high blood pressure and chronic kidney disease. We will also examine the molecular and epigenetic pathways affected by maternal perturbations that may give rise to a reduction in nephron number and subsequent alterations in renal function in adult life.

Original languageEnglish
Title of host publicationThe Epigenome and Developmental Origins of Health and Disease
PublisherAcademic Press
Pages291-314
Number of pages24
ISBN (Electronic)9780128013830
ISBN (Print)9780128016725
DOIs
Publication statusPublished - 2016
Externally publishedYes

Keywords

  • Hypertension
  • Kidney
  • Nephron number
  • Renal disease

Cite this

Cuffe, J. S. M., Walton, S. L., & Moritz, K. M. (2016). The Developmental Origins of Renal Dysfunction. In The Epigenome and Developmental Origins of Health and Disease (pp. 291-314). Academic Press. https://doi.org/10.1016/B978-0-12-801383-0.00015-3