The development of ionic liquids for biomedical applications - Prospects and challenges

Gloria D Elliott, Regina Kemp, Douglas R. MacFarlane

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Abstract

Ionic liquids have considerable potential to advance formulation science for protein-based pharmaceutical preparations and cellular therapies. Extended shelf life has been reported for a number of model proteins in rationally designed ionic liquid formulations (1-4). Biocompatibility is also an important aspect of rational design of pharmaceutical additives that are co-delivered into the body with a therapeutic. Using mouse macrophage cells as models for toxicity testing, biocompatibility has been established for a number of these bio-inspired ionic liquids, including salts based on the choline cation. Other important facets of clinical translation have also been elucidated. Here, we overview progress towards clinical application of ionic liquids and identify some of the challenges that remain.

Original languageEnglish
Pages (from-to)95-105
Number of pages11
JournalACS Symposium Series
Volume1030
DOIs
Publication statusPublished - 18 Dec 2009

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