The development of autonomic cardiovascular control is altered by preterm birth

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Abstract

OBJECTIVES: Autonomic dysfunction, either sympathetic or parasympathetic, may explain the increased incidence of Sudden Infant Death Syndrome (SIDS) among preterm infants, as well as their subsequent heightened risk of hypertension in adulthood. As little is known about the development of autonomic function in preterm infants, we contrasted autonomic cardiovascular control across the first 6months after term-corrected age (CA) in preterm and term infants. STUDY DESIGN: Preterm (n=25) and age matched term infants (n=31) were studied at 2-4weeks, 2-3months and 5-6months CA using daytime polysomnography. Blood pressure and heart rate were measured during quiet (QS) and active (AS) sleep. Autonomic control was assessed using spectral indices of blood pressure and heart rate variability (BPV and HRV) in ranges of low frequency (LF, reflecting sympathetic+parasympathetic activity), high frequency (HF, respiratory-mediated changes+parasympathetic activity), and LF/HF ratio (sympatho-vagal balance). RESULTS: In preterm infants, HF HRV increased, LF/HF HRV decreased and LF BPV decreased with age (p
Original languageEnglish
Pages (from-to)145 - 152
Number of pages8
JournalEarly Human Development
Volume89
Issue number3
DOIs
Publication statusPublished - 2013

Cite this

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title = "The development of autonomic cardiovascular control is altered by preterm birth",
abstract = "OBJECTIVES: Autonomic dysfunction, either sympathetic or parasympathetic, may explain the increased incidence of Sudden Infant Death Syndrome (SIDS) among preterm infants, as well as their subsequent heightened risk of hypertension in adulthood. As little is known about the development of autonomic function in preterm infants, we contrasted autonomic cardiovascular control across the first 6months after term-corrected age (CA) in preterm and term infants. STUDY DESIGN: Preterm (n=25) and age matched term infants (n=31) were studied at 2-4weeks, 2-3months and 5-6months CA using daytime polysomnography. Blood pressure and heart rate were measured during quiet (QS) and active (AS) sleep. Autonomic control was assessed using spectral indices of blood pressure and heart rate variability (BPV and HRV) in ranges of low frequency (LF, reflecting sympathetic+parasympathetic activity), high frequency (HF, respiratory-mediated changes+parasympathetic activity), and LF/HF ratio (sympatho-vagal balance). RESULTS: In preterm infants, HF HRV increased, LF/HF HRV decreased and LF BPV decreased with age (p",
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language = "English",
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The development of autonomic cardiovascular control is altered by preterm birth. / Yiallourou, Stephanie R; Witcombe, Nicole Brie; Sands, Scott; Walker, Adrian Mark; Horne, Rosemary Sylvia Claire.

In: Early Human Development, Vol. 89, No. 3, 2013, p. 145 - 152.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - The development of autonomic cardiovascular control is altered by preterm birth

AU - Yiallourou, Stephanie R

AU - Witcombe, Nicole Brie

AU - Sands, Scott

AU - Walker, Adrian Mark

AU - Horne, Rosemary Sylvia Claire

PY - 2013

Y1 - 2013

N2 - OBJECTIVES: Autonomic dysfunction, either sympathetic or parasympathetic, may explain the increased incidence of Sudden Infant Death Syndrome (SIDS) among preterm infants, as well as their subsequent heightened risk of hypertension in adulthood. As little is known about the development of autonomic function in preterm infants, we contrasted autonomic cardiovascular control across the first 6months after term-corrected age (CA) in preterm and term infants. STUDY DESIGN: Preterm (n=25) and age matched term infants (n=31) were studied at 2-4weeks, 2-3months and 5-6months CA using daytime polysomnography. Blood pressure and heart rate were measured during quiet (QS) and active (AS) sleep. Autonomic control was assessed using spectral indices of blood pressure and heart rate variability (BPV and HRV) in ranges of low frequency (LF, reflecting sympathetic+parasympathetic activity), high frequency (HF, respiratory-mediated changes+parasympathetic activity), and LF/HF ratio (sympatho-vagal balance). RESULTS: In preterm infants, HF HRV increased, LF/HF HRV decreased and LF BPV decreased with age (p

AB - OBJECTIVES: Autonomic dysfunction, either sympathetic or parasympathetic, may explain the increased incidence of Sudden Infant Death Syndrome (SIDS) among preterm infants, as well as their subsequent heightened risk of hypertension in adulthood. As little is known about the development of autonomic function in preterm infants, we contrasted autonomic cardiovascular control across the first 6months after term-corrected age (CA) in preterm and term infants. STUDY DESIGN: Preterm (n=25) and age matched term infants (n=31) were studied at 2-4weeks, 2-3months and 5-6months CA using daytime polysomnography. Blood pressure and heart rate were measured during quiet (QS) and active (AS) sleep. Autonomic control was assessed using spectral indices of blood pressure and heart rate variability (BPV and HRV) in ranges of low frequency (LF, reflecting sympathetic+parasympathetic activity), high frequency (HF, respiratory-mediated changes+parasympathetic activity), and LF/HF ratio (sympatho-vagal balance). RESULTS: In preterm infants, HF HRV increased, LF/HF HRV decreased and LF BPV decreased with age (p

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U2 - 10.1016/j.earlhumdev.2012.09.009

DO - 10.1016/j.earlhumdev.2012.09.009

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